School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
Fitoterapia. 2018 Jun;127:193-200. doi: 10.1016/j.fitote.2018.02.019. Epub 2018 Feb 15.
Five new schinortriterpenoids, propinqtrilactones A and B (1 and 2) with rare lancischiartane scaffold, and propindilactones V-X (3-5), were isolated from the stems and leaves of Schisandra propinqua var. propinqua. Their structures were elucidated on the basis of comprehensive spectroscopic and mass spectrometric analysis. The absolute configurations of 1-5 were determined by CD methods, X-ray diffraction analysis and theoretical calculations. 4 was tested for its cytotoxic activities against five human tumor cell lines.
从华中五味子的茎和叶中分离得到了五个新的石烷三萜，分别为 propinqtrilactones A 和 B（1 和 2），具有罕见的 lancischiartane 支架，以及 propindilactones V-X（3-5）。基于全面的光谱和质谱分析确定了它们的结构。通过 CD 方法、X 射线衍射分析和理论计算确定了 1-5 的绝对构型。对 4 进行了对五种人肿瘤细胞系的细胞毒性活性测试。
