Chair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Collegium Medicum, Jagiellonian University, Medyczna 9 Street, 30-688 Kraków, Poland.
Molecules. 2023 May 25;28(11):4333. doi: 10.3390/molecules28114333.
(Schisandraceae) is a plant species endemic to Yunnan Province in China and is little known in Europe and America. To date, few studies, mainly performed by Chinese researchers, have been conducted on . The chemical composition of this plant is dominated by lignans (dibenzocyclooctadiene, aryltetralin, dibenzylbutane), polyphenols (phenolic acids, flavonoids), triterpenoids, and nortriterpenoids. The research on the chemical profile of showed a similar chemical composition to -a globally known pharmacopoeial species with valuable medicinal properties whichis the best-known species of the genus Schisandra. The whole genus is characterized by the presence of the aforementioned specific dibenzocyclooctadiene lignans, known as "Schisandra lignans". This paper was intended to provide a comprehensive review of the scientific literature published on the research conducted on , with particular emphasis on the chemical composition and biological properties. Recently, a phytochemical, biological, and biotechnological study conducted by our team highlighted the great potential of in in vitro cultures. The biotechnological research revealed the possibilities of the use of biomass from as an alternative to raw material that cannot be easily obtained from natural sites. Moreover, the characterization of dibenzocyclooctadiene lignans specific to the Schisandraceae family was provided. Except for several scientific studies which have confirmed the most valuable pharmacological properties of these lignans, hepatoprotective and hepatoregenerative, this article also reviews studies that have confirmed the anti-inflammatory, neuroprotective, anticancer, antiviral, antioxidant, cardioprotective, and anti-osteoporotic effects and their application for treating intestinal dysfunction.
五味子科（Schisandraceae）是中国云南省特有的植物物种，在欧美鲜为人知。迄今为止，针对五味子的研究很少，主要由中国研究人员进行。该植物的化学成分主要由木脂素（双环[2.2.2]辛烷、芳基四氢萘、二苄基丁烷）、多酚（酚酸、类黄酮）、三萜和新三萜组成。对五味子的化学特性研究表明，其化学成分与全球知名的药用植物——五味——相似，五味是五味子属中最著名的物种。该属的特征是存在上述特定的双环[2.2.2]辛烷木脂素，称为“五味子木脂素”。本文旨在对已发表的关于五味子研究的科学文献进行全面综述，重点介绍其化学成分和生物特性。最近，我们团队进行的一项植物化学、生物学和生物技术研究强调了五味子在体外培养中的巨大潜力。生物技术研究揭示了利用五味子生物量作为替代难以从天然来源获得的原材料的可能性。此外，还对五味子科特有的双环[2.2.2]辛烷木脂素进行了特征描述。除了几项科学研究证实了这些木脂素具有最有价值的药理学特性，即保肝和肝再生外，本文还综述了证实其具有抗炎、神经保护、抗癌、抗病毒、抗氧化、心脏保护和抗骨质疏松作用的研究，以及它们在治疗肠道功能障碍方面的应用。
