Liu Miao, Wan Jun, Luo Yuan-Qing, Li Xiao-Nian, Du Xue, Pu Jian-Xin, Sun Han-Dong
Nat Prod Commun. 2016 Jul;11(7):925-929.
Four new triterpenoids, propindilactone T (1), propindilactone U (2), changnanic acid 3-methyl ester (3) and schipropinic. acid (4), together with five known ones (5-9), were isolated and identified from the stems and leaves of Schisandra propinqua var. propinqua; their structures were determined based on spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was confirmed by X-ray analysis. Compounds 1, 2, and 4-9 were tested for their cytotoxic activities against five human tumor cell lines; all were inactive except for 8, which showed weak activity against some of the cell lines.
从狭叶五味子变种狭叶五味子的茎和叶中分离并鉴定出4个新的三萜类化合物，丙酯内酯T（1）、丙酯内酯U（2）、长南酸3 - 甲酯（3）和裂环丙酯酸（4），以及5个已知化合物（5 - 9）；通过光谱和质谱分析确定了它们的结构。通过X射线分析确定了1的绝对构型。测试了化合物1、2和4 - 9对5种人肿瘤细胞系的细胞毒活性；除8对某些细胞系表现出弱活性外，其余均无活性。
