Department of Pharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
Department of Pharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.
Neuroscience. 2018 Apr 15;376:127-141. doi: 10.1016/j.neuroscience.2018.02.012. Epub 2018 Feb 14.
Alzheimer's disease (AD) is the leading cause of dementia worldwide. This pathological condition is characterized not only by Aβ and tau accumulation in the central nervous system (CNS), but also by inflammation, processes that can lead to neurodegeneration. Besides that, other factors may contribute to the development of AD, such as dyslipidemias. Changes in lipid levels can either influence the activity of enzymes related to the protein deposition that occurs in this pathological condition, or enhance the peripheral and CNS immune responses. Furthermore, cholesterol-associated genes are frequently associated with AD. Here, we extensively reviewed the literature and, based on the existing evidences, we suggest inflammation as an important link between dyslipidemias and AD.
阿尔茨海默病（AD）是全球范围内导致痴呆的主要原因。这种病理状况不仅以中枢神经系统（CNS）中 Aβ和 tau 的积累为特征，还以炎症为特征，这些过程可能导致神经退行性变。除此之外，其他因素也可能导致 AD 的发生，如血脂异常。脂质水平的变化既可以影响与该病理条件下发生的蛋白质沉积相关的酶的活性，也可以增强外周和中枢神经系统的免疫反应。此外，与胆固醇相关的基因通常与 AD 相关。在这里，我们广泛地回顾了文献，根据现有证据，我们认为炎症是血脂异常和 AD 之间的重要联系。
