School of Pharmaceutical Sciences, Lovely Professional University, Punjab 144 401, India.
School of Pharmaceutical Sciences, Lovely Professional University, Punjab 144 401, India.
Adv Colloid Interface Sci. 2018 Mar;253:35-65. doi: 10.1016/j.cis.2018.01.003. Epub 2018 Feb 7.
With the advent from the laboratory bench to patient bedside in last five decades, vesicular systems have now come to be widely accepted as pragmatic means for controlled delivery of drugs. Their success stories include those of liposomes, niosomes and even the lately developed ethosomes and transferosomes. Pharmacosomes, which, as delivery systems offer numerous advantages and have been widely researched, however, remain largely unacknowledged as a successful delivery system. Though a large number of drugs have been derivatized and formulated into self-assembled vesicular systems, the term pharmacosomes has not been widely used while reporting them. Therefore, their relative obscurity may be attributed to the non-usage of the nomenclature of pharmacosomes by the researchers working in the area. We present a review on the scenario that lead to origin of these bio-inspired vesicles composed of self-assembling amphiphilic molecules. Various drugs that have been formulated into pharmacosomes, their characterization techniques, their properties relative to those of other vesicular delivery systems, and the success achieved so far are also discussed.
在过去的五十年中，从实验室到患者床边，囊泡系统已被广泛认可为药物控释的实用手段。它们的成功案例包括脂质体、非离子型囊泡甚至最近开发的醇质体和转质体。尽管作为递药系统，药质体具有许多优势并得到了广泛研究，但作为一种成功的递药系统，它在很大程度上仍未得到认可。尽管已经有大量的药物被衍生和制成自组装囊泡系统，但在报道这些药物时，药质体一词并未被广泛使用。因此，研究人员在该领域不使用药质体这一命名可能是导致其相对不为人知的原因。我们对这些由自组装两亲分子组成的仿生囊泡的起源情况进行了综述。讨论了各种已被制成药质体的药物、它们的表征技术、它们相对于其他囊泡递药系统的性质以及迄今取得的成功。
