Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan.
Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal.
J Microencapsul. 2024 Sep;41(6):456-478. doi: 10.1080/02652048.2024.2376116. Epub 2024 Jul 11.
There are around 24 distinct lipid vesicles described in the literature that are similar to vesicular systems such as liposomes. Liposome-like structures are formed by combining certain amphiphilic lipids with a suitable stabiliser. Since their discovery and classification, self-assembled liposome-like structures as active drug delivery vehicles captured researchers' curiosity.
This comprehensive study included an in-depth literature search using electronic databases such as PubMed, ScienceDirect and Google Scholar, focusing on studies on liposome and liposomes like structure, discussed in literature till 2024, their sizes, benefits, drawback, method of preparation, characterisation and pharmaceutical applications.
Pharmacosomes, cubosomes, ethosomes, transethosomes, and genosomes, all liposome-like structures, have the most potential due to their smaller size with high loading capacity, ease of absorption, and ability to treat inflammatory illnesses. Genosomes are futuristic because of its affinity for DNA/gene transport, which is an area of focus in today's treatments.
This review will critically analyse the composition, preparation procedures, drug encapsulating technologies, drug loading, release mechanism, and related applications of all liposome-like structures, highlighting their potential benefits with enhanced efficacy over each other and over traditional carriers by paving the way for exploring novel drug delivery systems in the Pharma industry.
文献中描述了大约 24 种不同的脂质体，它们类似于脂质体等囊泡系统。脂质体样结构是通过将某些两亲性脂质与合适的稳定剂结合而形成的。自发现和分类以来，作为活性药物递送载体的自组装脂质体样结构引起了研究人员的兴趣。
本综合研究使用电子数据库（如 PubMed、ScienceDirect 和 Google Scholar）进行了深入的文献检索，重点关注截至 2024 年文献中讨论的关于脂质体和脂质体样结构的研究，包括它们的大小、优点、缺点、制备方法、特性和药物应用。
由于具有更小的尺寸、更高的载药能力、易于吸收以及治疗炎症疾病的能力，药质体、立方脂质体、醇质体、转醇质体和基因体等所有脂质体样结构都具有最大的潜力。由于其对 DNA/基因传递的亲和力，基因体是未来的方向，这是当今治疗的重点领域。
本文综述将批判性地分析所有脂质体样结构的组成、制备程序、药物包封技术、药物负载、释放机制以及相关应用，突出它们相对于彼此和传统载体的潜在优势，通过为制药行业探索新型药物递送系统铺平道路，提高疗效。
