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微血管减压术治疗面肌痉挛:痉挛治疗效果及并发症。综述

Microvascular decompression for hemifacial spasm: Outcome on spasm and complications. A review.

作者信息

Sindou M, Mercier P

机构信息

Clinique Bretéché, groupe ELSAN, 44000 Nantes, France.

Department of anatomy, UFR de médecine, university of Angers, rue haute de Reculée, 49045 Angers cedex, France.

出版信息

Neurochirurgie. 2018 May;64(2):106-116. doi: 10.1016/j.neuchi.2018.01.001. Epub 2018 Feb 15.

Abstract

Over the last decades microvascular decompression (MVD) has been established as the curative treatment of the primary Hemifacial Spasm (HFS), proven to be linked in almost all cases to a neurovascular compression of the facial nerve. Because the disease is not life-threatening and MVD not totally innocuous, efficacy and safety have to be weighted before decision taken of indicating surgery. The authors have been charged by the French Speaking Society of Neurosurgery to conduct a detailed evaluation of the probability of relief of the spasm that MVD is able to obtain, together with its potential complications. For the review, the authors have gone through the reports available from the Pubmed system. Eighty-two publications have been read and analysed, totalizing more than 10,000 operated cases. In most series, the percentage of patients with total relief ranged between 85% and 90%. Relief was obtained after a certain delay in as many as in 33%±8% of the patients in many series. For those, delay lasted around one year in 12% of them. When effect of MVD was considered achieved, relief remained permanent in all but 1%-2% of the long-term followed patients. As regards to complications, risk of permanent cranial nerve deficit was evaluated at 1%-2% for facial palsy, 2%-3% for non-functional hearing loss, 0.5%-1% for lower cranial nerve dysfunction. Risk of stroke was at 0.1% and mortality at 0.1%. CSF leakage and related complications could be reduced at less than 2% in most series provided careful closing techniques be applied. Complications were at a higher rate in repeated MVD. MVD is an effective curative method for almost all the patients affected with primary HFS. Because MVD for HFS is functional surgery, scrupulous consideration of its potential risks, together with the ways to avoid complications are of paramount importance. When MVD is estimated to have failed, it is wise to wait one year before considering to repeat surgery, as number of patients may benefit from delayed effect. This is the more so as important as repeated surgery entails a higher rate of complications.

摘要

在过去几十年中,微血管减压术(MVD)已成为原发性面肌痉挛(HFS)的根治性治疗方法,几乎在所有病例中都证明与面神经的神经血管压迫有关。由于该疾病不危及生命且MVD并非完全无害,因此在决定是否进行手术之前,必须权衡疗效和安全性。法语区神经外科学会委托作者对MVD能够缓解痉挛的可能性及其潜在并发症进行详细评估。为了进行综述,作者查阅了来自PubMed系统的可用报告。共阅读并分析了82篇出版物,总计超过10000例手术病例。在大多数系列中,完全缓解的患者百分比在85%至90%之间。在许多系列中,多达33%±8%的患者在一定延迟后获得缓解。其中,12%的患者延迟持续约一年。当认为MVD的效果已达成时,除了1%-2%的长期随访患者外,其余患者的缓解均保持永久。关于并发症,永久性颅神经缺损的风险评估为:面神经麻痹为1%-2%,功能性听力丧失为2%-3%,低位颅神经功能障碍为0.5%-1%。中风风险为0.1%,死亡率为0.1%。如果应用仔细的封闭技术,大多数系列中脑脊液漏及相关并发症可降至2%以下。重复MVD时并发症发生率更高。MVD是几乎所有原发性HFS患者的有效治疗方法。由于用于HFS的MVD是功能性手术,认真考虑其潜在风险以及避免并发症的方法至关重要。当估计MVD失败时,明智的做法是等待一年再考虑重复手术,因为一些患者可能会从延迟效应中受益。这一点尤为重要,因为重复手术会带来更高的并发症发生率。

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