Berent S, Giordani B, Lehtinen S, Markel D, Penney J B, Buchtel H A, Starosta-Rubinstein S, Hichwa R, Young A B
Department of Psychiatry, University of Michigan, Ann Arbor.
Ann Neurol. 1988 Jun;23(6):541-6. doi: 10.1002/ana.410230603.
Fifteen drug-free patients with early to mid-stage Huntington's disease (HD) were evaluated with positron emission tomographic (PET) scans of 18F-2-fluoro-2-deoxy-D-glucose uptake and quantitative measures of neurological function, learning, memory, and general intelligence. In comparison with a group of normal volunteers, the HD patients showed lower metabolism in both caudate (p less than 0.001) and putamen (p less than 0.001) on PET scans. A significant and positive relationship was found between neuropsychological measures of verbal learning and memory and caudate metabolism in the patient group but not in the normal group. Visual-spatial learning did not reflect a similar pattern, but performance intelligence quotient was positively related to both caudate and putamen metabolism in the HD group. Vocabulary level was unrelated to either brain structure. Discussion focuses on these and other observed brain-behavior relationships and on the implications of these findings for general behaviors such as those involved in coping and adaptation.
对15名处于亨廷顿舞蹈症（HD）早期至中期且未服用药物的患者进行了正电子发射断层扫描（PET），以检测其18F-2-氟-2-脱氧-D-葡萄糖摄取情况，并对神经功能、学习、记忆和一般智力进行定量测量。与一组正常志愿者相比，HD患者在PET扫描中显示尾状核（p<0.001）和壳核（p<0.001）的代谢均较低。在患者组中，言语学习和记忆的神经心理学测量与尾状核代谢之间存在显著正相关，而在正常组中则不存在。视觉空间学习未呈现类似模式，但在HD组中，操作智商与尾状核和壳核代谢均呈正相关。词汇水平与任何脑结构均无关联。讨论聚焦于这些以及其他观察到的脑-行为关系，以及这些发现对诸如应对和适应等一般行为的意义。
