低镁血症与慢性哮喘患者肺功能测试的关系。
The Relationship between Hypomagnesemia and Pulmonary Function Tests in Patients with Chronic Asthma.
机构信息
Department of Pulmonary Medicine, Ankara Atatürk Training and Research Hospital, Ankara, Turkey.
Department of Pulmonary Medicine, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
出版信息
Med Princ Pract. 2018;27(2):139-144. doi: 10.1159/000487760. Epub 2018 Feb 18.
OBJECTIVE
To investigate the relationship between serum values of magnesium and the parameters of the pulmonary function tests (PFT) in patients with chronic asthma.
SUBJECTS AND METHODS
This study recruited 50 patients with chronic stable asthma and 40 healthy individuals as a control group. Data on age, sex, severity of asthma, PFT, and details of drug therapy were obtained from each group. Serum magnesium, potassium, phosphorus, calcium, and sodium levels were also measured. To evaluate differences between groups, the Student t test or Mann-Whitney U test was performed for continuous variables, and the χ2 test for categorical variables.
RESULTS
In the asthma group, 10% (n = 9) of the patients had hypomagnesemia and 5.5% (n = 5) had hypophosphatemia. Patients with asthma were divided into two groups: the hypomagnesemic group (n = 9) and the normomagnesemic group (n = 41). Forced expiratory volume in 1 s (FEV1), FEV1%, peak expiratory flow (PEF), and PEF% were lower in the hypomagnesemic group than in the normomagnesemic group (p = 0.02). Multiple logistic regression analysis revealed a statistically significant association between hypomagnesemia and PFT in the hypomagnesemic asthmatic group. The correlations of age with FEV1, FEV1%, PEF, and PEF% were as follows: p = 0.00, r = 0.29; p = 0.00, r = 0.43; p = 0.03, r = 0.22; p = 0.00, r = 0.38; and p = 0.03, r = 0.22, respectively. The correlation of serum magnesium levels with PFT (FEV1, FEV1%, PEF, PEF%) were as follows: p = 0.001, r = 0.29; p = 0.001, r = 0.43; p = 0.03, r = 0.22; and p = 0.001, r = 0.38, respectively. The other electrolytes were within the normal range in both groups.
CONCLUSION
In this study, hypomagnesemia and hypophosphatemia were found to be the most common electrolyte abnormalities in patients with chronic stable asthma. FEV1, FEV1%, PEF, and PEF% were significantly lower in asthmatic patients with hypomagnesemia compared to asthmatic patients with normomagnesemia.
目的
探讨慢性哮喘患者血清镁值与肺功能检查（PFT）参数之间的关系。
对象和方法
本研究纳入了 50 例慢性稳定期哮喘患者和 40 名健康对照者。从每组中获取年龄、性别、哮喘严重程度、PFT 和药物治疗详细信息。还测量了血清镁、钾、磷、钙和钠水平。为评估组间差异，对连续变量采用学生 t 检验或曼-惠特尼 U 检验，对分类变量采用 χ2 检验。
结果
在哮喘组中，10%（n=9）的患者存在低镁血症，5.5%（n=5）存在低磷血症。将哮喘患者分为两组：低镁血症组（n=9）和正常镁血症组（n=41）。与正常镁血症组相比，低镁血症组患者的 1 秒用力呼气容积（FEV1）、FEV1%、呼气峰流速（PEF）和 PEF%均较低（p=0.02）。多因素逻辑回归分析显示，低镁血症与低镁血症哮喘组的 PFT 之间存在统计学显著关联。年龄与 FEV1、FEV1%、PEF 和 PEF%的相关性如下：p=0.00，r=0.29；p=0.00，r=0.43；p=0.03，r=0.22；p=0.00，r=0.38；p=0.03，r=0.22。血清镁水平与 PFT（FEV1、FEV1%、PEF、PEF%）的相关性如下：p=0.001，r=0.29；p=0.001，r=0.43；p=0.03，r=0.22；p=0.001，r=0.38。两组的其他电解质均在正常范围内。
结论
在本研究中，发现低镁血症和低磷血症是慢性稳定型哮喘患者最常见的电解质异常。与正常镁血症的哮喘患者相比，低镁血症的哮喘患者的 FEV1、FEV1%、PEF 和 PEF%显著降低。
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