Taha Mahmoud S, Almsned Fahad M, Hasen Mohammed, Atean Ibrahim M, Alwbari Ahmed M, Alharbi Qasim K, Abdulkader Marwah M, Almuhaish Husam S
Department of Neurosurgery, King Fahad Specialist Hospital, Dammam, Kingdom of Saudi Arabia. E-mail:
Neurosciences (Riyadh). 2018 Jan;23(1):18-22. doi: 10.17712/nsj.2018.1.20160543.
To review the demographic and pathological pattern of neuro-epithelial brain tumors in a tertiary referral center in the Eastern Province of Saudi Arabia and to compare the results of our study with other national and international studies.
This is a retrospective chart-review study of all patients with neuro-epithelial brain tumors referred and treated in our center between January 2010 and January 2015. The age, gender, tumor location, and histopathology were recorded.
The total number of cases was 149 including 96 adult cases and 53 pediatric cases. 58% of cases were male, and 42% were female. The age group distribution showed 2 peaks; one in the first 5 years of life and the second was in the age range from 26-45 years old. Glioblastoma multiforme was the most common pathological type (32%), followed by medulloblastoma (13.3%). This study showed similar results to a previous study conducted in the Eastern Province in terms of age and gender distribution, but pathologically, the tumors diagnosed in our study were generally of a higher grading. When comparing our results to other international studies in nearby countries (Jordan and Egypt), we found similarities in pathological patterns and age distribution. However, when comparing our results to a western country (USA), we found considerable differences in the age group distribution.
Neuro-epithelial brain tumors in Saudi Arabia affect younger population according to our study compared to Western countries. These findings are similar to other studies from Middle Eastern countries. In addition, our study showed a significant increase in high grade gliomas in the Eastern Province compared to an old historical study. This increase should be interpreted cautiously due to possible selection errors, changes in pathological grading, and expertise.
回顾沙特阿拉伯东部某三级转诊中心神经上皮性脑肿瘤的人口统计学和病理模式，并将我们的研究结果与其他国内和国际研究进行比较。
这是一项对2010年1月至2015年1月期间在我们中心转诊和治疗的所有神经上皮性脑肿瘤患者进行的回顾性图表审查研究。记录了年龄、性别、肿瘤位置和组织病理学。
病例总数为149例，其中成人病例96例，儿童病例53例。58%的病例为男性，42%为女性。年龄组分布显示有两个高峰；一个在生命的前5年，另一个在26 - 45岁年龄范围内。多形性胶质母细胞瘤是最常见的病理类型（32%），其次是髓母细胞瘤（13.3%）。本研究在年龄和性别分布方面显示出与之前在东部省份进行的一项研究相似的结果，但在病理上，我们研究中诊断出的肿瘤分级普遍较高。当将我们的结果与附近国家（约旦和埃及）的其他国际研究进行比较时，我们发现病理模式和年龄分布存在相似之处。然而，当将我们的结果与西方国家（美国）进行比较时，我们发现年龄组分布存在相当大的差异。
根据我们的研究，与西方国家相比，沙特阿拉伯的神经上皮性脑肿瘤影响的是更年轻的人群。这些发现与中东国家的其他研究相似。此外，与一项历史悠久的研究相比，我们的研究显示东部省份高级别胶质瘤显著增加。由于可能存在的选择误差、病理分级变化和专业知识等因素，对这一增加应谨慎解读。
