Almutrafi Amna, Bashawry Yara, AlShakweer Wafaa, Al-Harbi Musa, Altwairgi Abdullah, Al-Dandan Sadeq
Department of Anatomical Pathology, King Fahad Medical City, Riyadh, Saudi Arabia.
Department of Pathology, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
J Cancer Epidemiol. 2020 Feb 15;2020:1429615. doi: 10.1155/2020/1429615. eCollection 2020.
This study is aimed at describing the epidemiological trends of primary CNS tumors in children and adults at the National Neurologic Institute in Saudi Arabia.
A retrospective epidemiological approach was used where data was obtained from the department of pathology registry files and pathology reports. The records of all patients registered from January 2005 to December 2014 with a diagnosis of primary CNS tumor (brain and spinal cord) were selected. Data about sex, age, tumor location, and histologic type were collected. The classification was based on the International Classification of Diseases for Oncology, 3rd Edition (ICD-O-3).
Nine hundred and ninety-two (992) cases of primary CNS tumors throughout the ten years (2005 to 2014) were reviewed. There were 714 (71.97%) adults and 278 (28.02%) in the pediatric age group. Nonmalignant tumors dominated the adult population (60.08%) while malignant tumors were more frequent in the pediatric population. Gliomas constituted the most common neoplastic category in children and adults. The most common single tumor entity was meningioma (26.99%, ICD-O-3 histology codes 9530/0, 9539/1, and 9530/3). Medulloblastomas (ICD-O-3 histology codes 9470, 9471, and 9474) were the most common single tumor entity in the pediatric age group (26.62%).
This is an institution-based, detailed, and descriptive epidemiological study of patients with primary CNS tumors in Saudi Arabia. In contrast to other regional and international studies, the medulloblastomas in our institution are more frequent than pilocytic astrocytomas. Limitations to our study included the referral bias and histology-based methodology.
本研究旨在描述沙特阿拉伯国家神经研究所儿童和成人原发性中枢神经系统肿瘤的流行病学趋势。
采用回顾性流行病学方法，从病理登记档案和病理报告部门获取数据。选取2005年1月至2014年12月期间登记的所有诊断为原发性中枢神经系统肿瘤（脑和脊髓）的患者记录。收集有关性别、年龄、肿瘤位置和组织学类型的数据。分类基于国际肿瘤疾病分类第3版（ICD-O-3）。
回顾了十年间（2005年至2014年）992例原发性中枢神经系统肿瘤病例。成人有714例（71.97%），儿童年龄组有278例（28.02%）。非恶性肿瘤在成人中占主导（60.08%），而恶性肿瘤在儿童中更常见。胶质瘤是儿童和成人中最常见的肿瘤类别。最常见的单一肿瘤实体是脑膜瘤（26.99%，ICD-O-3组织学编码9530/0、9539/1和9530/3）。髓母细胞瘤（ICD-O-3组织学编码9470、9471和9474）是儿童年龄组中最常见的单一肿瘤实体（26.62%）。
这是一项基于机构的、详细的沙特阿拉伯原发性中枢神经系统肿瘤患者描述性流行病学研究。与其他区域和国际研究相比，我们机构的髓母细胞瘤比毛细胞性星形细胞瘤更常见。我们研究的局限性包括转诊偏倚和基于组织学的方法。
