Postdoctoral researcher, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Carbohydr Polym. 2018 Apr 15;186:384-393. doi: 10.1016/j.carbpol.2017.12.081. Epub 2018 Jan 2.
In the current study, a set of biodegradable soybean polysaccharide (SSPS) nanocomposites containing different ratios of TiO nanoparticles was characterized as new packaging system. X-ray diffraction (XRD) measurement showed that the crystalline structure of the TiO nanoparticles remained intact in the polysaccharide matrix and the surface of nanocomposites containing 1-3% TiO was observed morphologically uniform under scanning electron microscopy (SEM). Dynamic mechanical thermal analysis revealed that the magnitude of storage modulus was 3.62-fold higher in SPSS/TiO nanocomposites containing 7 wt.% of TiO than control SSPS indicating improvement in the physical properties of the film supposed to be utilized for food packaging. With respect to the concern over the safety of these nanocomposites, inductively coupled plasma-optical emission spectroscopy (ICP-OES) showed that no TiO was detected in bread samples covered by SSPS/TiO film and stored for 6 months. Similarly, the nanocomposite films only released a minuscule amount (21.05 ± 0.054 ppm) of TiO in water. TiO nanoparticles were found in the plasma membrane of epithelial cell line after long-term exposure (10-day) of these cells to large amounts of the free nanoparticles. SSPS/TiO nanocomposites showed excellent antimicrobial activity against Staphylococcus aureus PTCC 1431 (ATCC 25923), while neither anti-cancerous nor pro-cancerous activity was observed for these nanocomposites denoting their neutrality with respect to cancer suppression or progression in gastrointestinal tract. In conclusion, SSPS/TiO nanocomposites could be a promising packaging system for food industries' objective regarding their physical characteristics, low rate of Ti transition, and low health risk.
在本研究中，一组含有不同比例 TiO2 纳米粒子的可生物降解大豆多糖 (SSPS) 纳米复合材料被表征为新型包装系统。X 射线衍射 (XRD) 测量表明，TiO2 纳米粒子的晶体结构在多糖基质中保持完整，并且扫描电子显微镜 (SEM) 观察到含有 1-3%TiO2 的纳米复合材料表面形态均匀。动态力学热分析表明，含有 7wt.%TiO2 的 SSPS/TiO 纳米复合材料的储能模量比对照 SSPS 高 3.62 倍，表明薄膜的物理性能得到了改善，有望用于食品包装。关于这些纳米复合材料的安全性问题，电感耦合等离子体 - 光学发射光谱 (ICP-OES) 表明，用 SSPS/TiO 薄膜覆盖并储存 6 个月的面包样品中未检测到 TiO2。同样，纳米复合膜在水中仅释放出微量的 TiO2（21.05±0.054ppm）。在这些细胞长期暴露（10 天）于大量游离纳米颗粒后，发现 TiO2 纳米颗粒存在于上皮细胞系的质膜中。SSPS/TiO 纳米复合材料对金黄色葡萄球菌 PTCC 1431（ATCC 25923）表现出优异的抗菌活性，而这些纳米复合材料既没有抗癌活性也没有促癌活性，这表明它们在胃肠道中对癌症抑制或进展具有中性作用。总之，SSPS/TiO 纳米复合材料可能是食品工业有前途的包装系统，因为它们具有物理特性、Ti 转化率低和低健康风险。
