Shah Mishal Piyush, Gujjari Sheela Kumar, Chandrasekhar Veerendrakumar Siddhpur
Department of Periodontology, Narsinhbhai Patel Dental College, Visnagar, Gujarat, India.
JSS Dental College, Mysore, Karnataka, India.
J Indian Soc Periodontol. 2017 Jul-Aug;21(4):341-343. doi: 10.4103/jisp.jisp_215_17.
The over usage and broad use of antibiotics resulted in the emergence of resistant microorganisms to the drugs which also disturb the indigenous microflora, which include the in the oral cavity. Hence, it is preferred to avoid the use of antibiotics.
The hypothesis tested in this study was that 14 days of treatment with CD2 lozenges, CD2 with oral doxycycline, or doxycycline alone would have a beneficial effect on periodontal health after 5 months.
It was a randomized clinical trial.
Eighteen nonsmoking patients aged 14-35 years, with aggressive periodontitis, were randomized to receive 14 days of treatment with CD2 lozenges (two lozenges daily), CD2 lozenges with oral doxycycline (100 mg tablet once daily), or doxycycline alone. Saliva samples were taken on day 0, 2 weeks, 2 months, and 5 months. Clinical parameters (plaque index, gingival index, probing pocket depth, and clinical attachment level) and microbiological parameters (lactobacilli and ) were evaluated.
Changes between groups were evaluated using repeated measure analysis of variance.
All clinical parameters shown to be numerically improved at 5 months when compared with baseline in all the three groups. The improvement ( < 0.01) in gingival index was statistically significant, and the intergroup results were also statistically significant ( < 0.01).
Fourteen days of treatment with lozenges having CD2 have a lasting effect on clinical measures of aggressive periodontitis, particularly gingival index. This effect appears to be equivalent to that produced by doxycycline.
抗生素的过度使用和广泛应用导致了对药物产生耐药性的微生物的出现，这也扰乱了包括口腔内微生物群在内的本土微生物群落。因此，最好避免使用抗生素。
本研究检验的假设是，使用含CD2含片、含口服强力霉素的CD2或单独使用强力霉素治疗14天，5个月后对牙周健康将产生有益影响。
这是一项随机临床试验。
18名年龄在14 - 35岁、患有侵袭性牙周炎的非吸烟患者被随机分为三组，分别接受含CD2含片（每日两片）、含口服强力霉素（每日100毫克片剂）的CD2含片或单独使用强力霉素治疗14天。在第0天、2周、2个月和5个月采集唾液样本。评估临床参数（菌斑指数、牙龈指数、探诊袋深度和临床附着水平）和微生物学参数（乳酸杆菌和[此处原文缺失相关微生物名称]）。
使用重复测量方差分析评估组间变化。
与基线相比，所有三组在5个月时所有临床参数在数值上均有所改善。牙龈指数的改善（P < 0.01）具有统计学意义，组间结果也具有统计学意义（P < 0.01）。
含CD2的含片治疗14天对侵袭性牙周炎的临床指标，尤其是牙龈指数有持久影响。这种效果似乎与强力霉素产生的效果相当。
