Baltacioglu Esra, Aslan Malike, Saraç Özlem, Saybak Arif, Yuva Pinar
Karadeniz Technical University, Faculty of dentistry, Department of periodontology, 61080 Trabzon, Turkey.
J Can Dent Assoc. 2011;77:b97.
To assess the clinical benefit of either metronidazole and amoxicillin or doxycycline administered immediately after completion of full-mouth scaling and root planing (FRP) for treatment of generalized aggressive periodontitis.
Patients, 18 to 40 years of age, referred to the Karadeniz Technical University department of periodontology between January 2009 and September 2009 were randomly chosen for inclusion in the study if radiographic examination showed they had ≥ 20 teeth, clinical attachment loss and a probing pocket depth (PPD) ≥ 6 mm at 2 sites in ≥ 12 teeth, ≥ 3 of which were not first molars or incisors. Patients were divided into 3 groups and received FRP alone, FRP combined with metronidazole and amoxicillin, or FRP combined with doxycycline. PPD, clinical attachment level, gingival index, gingival bleeding index and plaque index values were measured at baseline and 2 months after treatment.
Thirty-eight patients with untreated generalized aggressive periodontitis participated in the study. In all 3 groups, the periodontal index values 2 months after treatment were significantly lower than baseline values (p < 0.05). Values for PPD and clinical attachment level were more improved in the antibiotic groups than in the FRP group, and more improved in the metronidazole and amoxicillin group than in the doxycycline group (p < 0.05). However, no statistically significant intergroup difference was observed in the other clinical parameters (p > 0.05). Systemic use of metronidazole and amoxicillin or doxycycline was clinically superior to FRP for reducing PPDs ≥ 7 mm (p < 0.05).
Treatment of generalized aggressive periodontitis with FRP alone or FRP combined with systemic antibiotics provided significant clinical benefits that reduced the need for periodontal surgery. Both antibiotic treatments had additional clinical benefits over those of FRP alone.
评估在全口洁治和根面平整（FRP）完成后立即给予甲硝唑和阿莫西林或强力霉素治疗广泛侵袭性牙周炎的临床疗效。
选取2009年1月至2009年9月间转诊至黑海技术大学牙周病科、年龄在18至40岁之间的患者，若影像学检查显示其有≥20颗牙齿，临床附着丧失且≥12颗牙齿中至少2个位点的探诊深度（PPD）≥6mm，其中≥3颗不是第一磨牙或切牙，则随机纳入本研究。患者分为3组，分别接受单纯FRP治疗、FRP联合甲硝唑和阿莫西林治疗或FRP联合强力霉素治疗。在基线和治疗后2个月测量PPD、临床附着水平、牙龈指数、牙龈出血指数和菌斑指数值。
38例未经治疗的广泛侵袭性牙周炎患者参与了本研究。所有3组治疗后2个月的牙周指数值均显著低于基线值（p<0.05）。抗生素组的PPD和临床附着水平值比FRP组改善更明显，甲硝唑和阿莫西林组比强力霉素组改善更明显（p<0.05）。然而，在其他临床参数方面未观察到组间统计学显著差异（p>0.05）。全身使用甲硝唑和阿莫西林或强力霉素在减少PPD≥7mm方面在临床上优于FRP（p<0.05）。
单纯FRP或FRP联合全身抗生素治疗广泛侵袭性牙周炎可带来显著的临床益处，减少了牙周手术的需求。两种抗生素治疗均比单纯FRP具有额外的临床益处。
