Hammad Mohamed Anwar, Tangiisuran Balamurugan, Kharshid Abeer Mohamed, Abdul-Aziz Noorizan, Hassan Yahaya, Aziz Nor Azizah, Elsayed Tarek Mohamed
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Department of Pharmacy Practice, Universiti Teknologi Mara, Shah Alam, Malaysia.
J Pharm Bioallied Sci. 2017 Oct-Dec;9(4):221-228. doi: 10.4103/jpbs.JPBS_26_17.
The literature of drug-drug interaction (DDI)-related uncontrolled causality, and preventability of DDI-induced UCG (HbA1c >7%) in outpatients glycemia (UCG) among outpatients with Type 2 diabetes mellitus is still limited.
The aim of this study is to identify the prevalence, mechanism, severity, with Type 2 diabetes.
A cross-sectional study was conducted in Penang General Hospital.
A computerized system for DDI checking was used to assess the severity and mechanism of DDIs. Drug interaction probability scale was used to evaluate the likelihood of DDIs. Preventability of DDIs has been determined by the instrument of Hallas. The UCG prevalence related to DDIs was further assessed.
SPSS 21.00 was used in this study.
From 425 outpatients with HbA1c% test, their mean age was 58.7 ± 12.8 years. Only 225 (52.9%) cases had controlled glycemia while 200 (47.1%) cases with UCG. They had multiple comorbidities, with a mean number of 3.8 ± 2.2/patient and often prescribed with multiple medications, with a mean number of 6.33 ± 4.67/patient. It has been detected that 86 DDIs causing UCG in 46 patients (23%) with range of (1 - 4) DDIs per patient. Drugs with DDI-induced UCG were as follows: diuretics (79%), salbutamol (9.2%), cortisones (5.8%), and others (6%). The majority of these DDIs were categorized as possible (77.9%) and preventable (37%).
Nearly one-quarter of UCG was induced by DDIs; most of these DDIs are possible, and more than one-third are preventable. It was concluded that thiazide diuretics have the highest prevalence of DDI-related UCG.
关于2型糖尿病门诊患者中药物相互作用（DDI）相关的未控制因果关系以及DDI诱发血糖未控制（UCG，糖化血红蛋白>7%）的可预防性的文献仍然有限。
本研究的目的是确定2型糖尿病患者中DDI的患病率、机制、严重程度。
在槟城总医院进行了一项横断面研究。
使用计算机化的DDI检查系统评估DDI的严重程度和机制。使用药物相互作用概率量表评估DDI的可能性。DDI的可预防性已通过哈拉斯工具确定。进一步评估了与DDI相关的UCG患病率。
本研究使用SPSS 21.00。
在425例进行糖化血红蛋白检测的门诊患者中，他们的平均年龄为58.7±12.8岁。只有225例（52.9%）患者血糖得到控制，而200例（47.1%）患者血糖未控制。他们有多种合并症，平均每位患者3.8±2.2种，并且经常同时服用多种药物，平均每位患者6.33±4.67种。已检测到46例患者（23%）中有86例DDI导致UCG，每位患者的DDI范围为（1 - 4）种。导致UCG的DDI相关药物如下：利尿剂（79%）、沙丁胺醇（9.2%）、皮质激素（5.8%）和其他药物（6%）。这些DDI大多数被归类为可能的（77.9%）和可预防的（37%）。
近四分之一的UCG是由DDI诱发的；这些DDI大多数是可能的，并且超过三分之一是可预防的。得出的结论是，噻嗪类利尿剂与DDI相关的UCG患病率最高。
