Scratching the Surface of Werner Syndrome and Human Ageing.
作者信息
Poot Martin
出版信息
Mol Syndromol. 2017 Dec;9(1):1-4. doi: 10.1159/000484424. Epub 2017 Nov 23.
Abstract
摘要
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Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype.WRN 解旋酶失活变异型 R834C 的纯合子并不导致 Werner 综合征临床表型。
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DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy.个体年龄相关的CpG位点处的DNA甲基化水平可用于指示预期寿命。
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Science. 2015 Jun 5;348(6239):1160-3. doi: 10.1126/science.aaa1356. Epub 2015 Apr 30.
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