Thanooja C V, Augustine Ann Mary, Lepcha Anjali, Sandhya Pulukool, Tyagi Amit Kumar, Danda Debashish, Balraj Achamma
1Department of ENT, Christian Medical College, Vellore, India.
2Department of Rheumatology, Christian Medical College, Vellore, India.
Indian J Otolaryngol Head Neck Surg. 2018 Mar;70(1):59-65. doi: 10.1007/s12070-015-0956-y. Epub 2015 Dec 17.
This study aims to assess the frequency and the profile of hearing loss among patients with primary Sjögren's syndrome in a tertiary care hospital in India and to look for an association between hearing loss and immunological parameters (anti-SSA antibody, anti-SSB antibody, anticardiolipin antibodies, complements C3 and C4). This prospective observational study was done from January 2011 to October 2011 on consecutive patients diagnosed with primary Sjögren's syndrome in our tertiary care hospital. All patients underwent a puretone audiogram, tympanogram and acoustic reflex testing. The results of the tests were correlated with clinical and immunological findings. The frequency of audiometrically confirmed hearing loss in primary Sjögren's syndrome was estimated to be 78.38 %, though only 17.24 % complained of hearing loss; minimal to mild sensorineural hearing loss were the most common varieties. The commonest finding on tympanometry was 'A' type curve and acoustic reflex was absent in 18.92 % of cases. There was no association between hearing loss and age, sicca symptoms, systemic symptoms or immunological test results in primary Sjögren's syndrome. There was a high prevalence of hearing loss among patients with primary Sjögren's syndrome, but most patients were unaware of this. Hearing assessment and regular monitoring of hearing thresholds is advisable for all patients with primary Sjögren's syndrome.
本研究旨在评估印度一家三级护理医院中原发性干燥综合征患者听力损失的发生率和特征，并探寻听力损失与免疫参数（抗SSA抗体、抗SSB抗体、抗心磷脂抗体、补体C3和C4）之间的关联。这项前瞻性观察性研究于2011年1月至2011年10月在我们的三级护理医院对连续诊断为原发性干燥综合征的患者进行。所有患者均接受了纯音听力图、鼓室图和声反射测试。测试结果与临床和免疫学检查结果相关联。原发性干燥综合征中经听力测定确诊的听力损失发生率估计为78.38%，尽管只有17.24%的患者主诉有听力损失；轻度至中度感音神经性听力损失是最常见的类型。鼓室图最常见的结果是“A”型曲线，18.92%的病例声反射消失。原发性干燥综合征患者的听力损失与年龄、干燥症状、全身症状或免疫测试结果之间无关联。原发性干燥综合征患者中听力损失的患病率较高，但大多数患者并未意识到这一点。对于所有原发性干燥综合征患者，建议进行听力评估并定期监测听力阈值。
