Department of Otorhinolaryngology, Taipei City Hospital, Taipei, Taiwan.
Department of Speech, Language and Audiology, National Taipei University of Nursing and Health, Taipei, Taiwan.
RMD Open. 2024 Jan 19;10(1):e003308. doi: 10.1136/rmdopen-2023-003308.
This study aimed to provide an updated prevalence of hearing loss, tinnitus, vertigo and sudden deafness on patients with Sjögren's syndrome and matched comparison patients.
Data for this study were retrieved from the Taiwan Longitudinal Health Insurance Database and Taiwan's registered catastrophic illness dataset. This study included 20 266 patients with Sjögren's syndrome as the study group and 60 798 propensity score-matched comparison patients as the comparison group. We used multivariable logistic regressions to estimate the ORs and 95% CI for tinnitus, hearing loss, vertigo and sudden deafness among Sjögren's syndrome patients versus comparison patients.
χ tests showed there were statistically significant differences between the study group and comparison group in the prevalence of tinnitus (10.1% vs 6.3%, p<0.001), hearing loss (5.6% vs 3.3%, p0.001), vertigo (4.6% vs 3.2%, p<0.001) and sudden deafness (0.8% vs 0.6%, p<0.001). Multiple logistic regression revealed that patients with Sjögren's syndrome had a greater tendency to have tinnitus (OR=1.690, 95% CI 1.596-1.788), sudden deafness (OR=1.368, 95% CI 1.137-1.647), hearing loss (OR=1.724, 95% CI 1.598-1.859) and vertigo (OR=1.473, 95% CI 1.360-1.597) relative to comparison patients after adjusting for age, income, geographic location, residential urbanisation level, diabetes, hypertension, hyperlipidaemia and rheumatoid arthritis.
We found higher prevalence of hearing loss, vertigo, tinnitus and sudden deafness among patients with Sjögren's syndrome relative to comparison patients. Findings may provide guidance to physicians in counselling patients with Sjögren's syndrome regarding a higher risk of hearing loss, tinnitus, sudden deafness and vertigo.
本研究旨在提供干燥综合征患者听力损失、耳鸣、眩晕和突发性聋的最新患病率，并与匹配的对照患者进行比较。
本研究的数据来自于台湾地区的纵向健康保险数据库和登记的灾难性疾病数据库。研究纳入了 20266 例干燥综合征患者作为研究组，60798 例按倾向评分匹配的对照患者作为对照组。我们使用多变量逻辑回归来估计干燥综合征患者与对照患者之间耳鸣、听力损失、眩晕和突发性聋的比值比（OR）和 95%置信区间（CI）。
卡方检验显示，研究组与对照组在耳鸣（10.1%比 6.3%，p<0.001）、听力损失（5.6%比 3.3%，p<0.001）、眩晕（4.6%比 3.2%，p<0.001）和突发性聋（0.8%比 0.6%，p<0.001）的患病率方面存在统计学显著差异。多因素逻辑回归显示，与对照患者相比，干燥综合征患者发生耳鸣（OR=1.690，95%CI 1.596-1.788）、突发性聋（OR=1.368，95%CI 1.137-1.647）、听力损失（OR=1.724，95%CI 1.598-1.859）和眩晕（OR=1.473，95%CI 1.360-1.597）的可能性更大，调整年龄、收入、地理位置、居住城市化水平、糖尿病、高血压、高脂血症和类风湿关节炎后差异仍有统计学意义。
我们发现干燥综合征患者听力损失、眩晕、耳鸣和突发性聋的患病率高于对照患者。这些发现可能为医生向干燥综合征患者提供咨询提供指导，告知其听力损失、耳鸣、突发性聋和眩晕的风险较高。
