槲皮素可防止大鼠因使用超顺磁性氧化铁纳米颗粒而导致体重减轻。
Quercetin Prevents Body Weight Loss Due to the Using of Superparamagnetic Iron Oxide Nanoparticles in Rat.
作者信息
Najafabadi Rezvan Enteshari, Kazemipour Nasrin, Esmaeili Abolghasem, Beheshti Siamak, Nazifi Saeed
机构信息
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Department of Biology, Cell, Molecular Biology and Biochemistry Division, Faculty of Sciences, University of Isfahan, Isfahan, Iran.
出版信息
Adv Biomed Res. 2018 Jan 30;7:8. doi: 10.4103/abr.abr_141_17. eCollection 2018.
BACKGROUND
Superparamagnetic iron oxide nanoparticles (SPION) have been largely considered for numerous applications in biomedicine such as magnetic resonance imaging, hyperthermia, cell tracking, anticancer treatment, and targeted delivery of drugs or genes. However, they may have side effects such body weight loss. Quercetin (QT), a strong antioxidant and free radical scavenger and a natural flavonoid, has a wide range of biological and therapeutic effects. In this study, the effect of QT on prevention of weight loss due to the using of SPION has been investigated.
MATERIALS AND METHODS
SPION and QT-SPION were administered orally at 50 and 100 mg/kg for 7 days. Then, the body weight was measured at the beginning and the end of the study.
RESULTS
Rats fed with 50 and 100 mg/kg SPION showed a significant weight loss, whereas those that fed with 50 mg/kg QT-SPION did not. A weight loss was observed in rats treated with 100 mg/kg of QT-SPION.
CONCLUSIONS
The results of this study showed that quercetin could prevent weight loss due to the SPION.
背景
超顺磁性氧化铁纳米颗粒（SPION）在生物医学的众多应用中得到了广泛的考虑，如磁共振成像、热疗、细胞追踪、抗癌治疗以及药物或基因的靶向递送。然而，它们可能有诸如体重减轻等副作用。槲皮素（QT）是一种强大的抗氧化剂和自由基清除剂，也是一种天然黄酮类化合物，具有广泛的生物学和治疗作用。在本研究中，研究了QT对预防因使用SPION导致的体重减轻的作用。
材料与方法
以50和100mg/kg的剂量口服给予SPION和QT-SPION，持续7天。然后，在研究开始和结束时测量体重。
结果
喂食50和100mg/kg SPION的大鼠体重显著减轻，而喂食50mg/kg QT-SPION的大鼠体重未减轻。用100mg/kg QT-SPION处理的大鼠体重减轻。
结论
本研究结果表明，槲皮素可以预防因SPION导致的体重减轻。
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