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超顺磁性氧化铁纳米颗粒的尺寸隔离改善了 MRI、MPI 和热疗性能。

Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance.

机构信息

Institute for Experimental Molecular Imaging, Faculty of Medicine, RWTH Aachen University, Forckenbeckstr. 55, 52074, Aachen, Germany.

Department of Biomolecular Sciences, University of Urbino 'Carlo Bo', Via Aurelio Saffi 2, 61029, Urbino, Italy.

出版信息

J Nanobiotechnology. 2020 Jan 28;18(1):22. doi: 10.1186/s12951-020-0580-1.

DOI:10.1186/s12951-020-0580-1
PMID:31992302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6986086/
Abstract

Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist® and Sinerem®. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications.

摘要

超顺磁性氧化铁纳米粒子（SPION）广泛应用于磁共振成像（MRI）和磁共振粒子成像（MPI），以及磁流体热疗（MFH）。我们在这里描述了一种顺序离心方案，用于从使用常规共沉淀技术合成的多分散性 SPION 起始制剂中获得具有明确定义尺寸的 SPION。透射电子显微镜、动态光散射和纳米颗粒跟踪分析表明，通过尺寸分离获得的 SPION 分数是明确的，几乎是单分散的。与多分散起始混合物以及与 Resovist®和 Sinerem®等商业和临床应用的氧化铁纳米颗粒制剂相比，尺寸分离的 SPION 的 MRI、MPI 和 MFH 分析显示出更好的成像和热疗性能。这里提出的尺寸分离方案可能有助于鉴定出具有诊断、治疗和治疗诊断应用最佳性能的 SPION。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/ae2d10920f77/12951_2020_580_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/84b244739464/12951_2020_580_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/a112193a4ac3/12951_2020_580_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/91eac6a1fc6b/12951_2020_580_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/4b8092c72fef/12951_2020_580_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/5c147047c38d/12951_2020_580_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/ae2d10920f77/12951_2020_580_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/84b244739464/12951_2020_580_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/a112193a4ac3/12951_2020_580_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/91eac6a1fc6b/12951_2020_580_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/4b8092c72fef/12951_2020_580_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/5c147047c38d/12951_2020_580_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9901/6986086/ae2d10920f77/12951_2020_580_Fig6_HTML.jpg

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本文引用的文献

[1]
Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro.

Nanotechnology. 2019-1-30

[2]
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications.

Adv Drug Deliv Rev. 2019-1-11

[3]
Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells.

Sci Rep. 2018-9-4

[4]
Enhanced Methods to Estimate the Efficiency of Magnetic Nanoparticles in Imaging.

Molecules. 2017-12-12

[5]
Thermal Decomposition Synthesis of Iron Oxide Nanoparticles with Diminished Magnetic Dead Layer by Controlled Addition of Oxygen.

ACS Nano. 2017-2-14

[6]
Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications.

Sci Technol Adv Mater. 2015-4-28

[7]
Design of iron oxide-based nanoparticles for MRI and magnetic hyperthermia.

Nanomedicine (Lond). 2016-7

[8]
Purification of Nanoparticles by Size and Shape.

Sci Rep. 2016-6-8

[9]
Influence of the separation procedure on the properties of magnetic nanoparticles: Gaining in vitro stability and T1-T2 magnetic resonance imaging performance.

J Colloid Interface Sci. 2016-3-19

[10]
Imalytics Preclinical: Interactive Analysis of Biomedical Volume Data.

Theranostics. 2016-1-1

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