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利用双光子磷光铱(III)配合物追踪细胞凋亡过程中的线粒体pH波动

Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent iridium(iii) complexes.

作者信息

Qiu Kangqiang, Ke Libing, Zhang Xuepeng, Liu Yukang, Rees Thomas W, Ji Liangnian, Diao Jiajie, Chao Hui

机构信息

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China.

Lab of Computational and Drug Design, Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, P. R. China.

出版信息

Chem Commun (Camb). 2018 Mar 7;54(19):2421-2424. doi: 10.1039/c8cc00299a. Epub 2018 Feb 19.

Abstract

Two iridium(iii) complexes with ligands containing morpholine groups were used to track mitochondrial pH fluctuation during cell apoptosis as their emissive intensities linearly increased with increase in pH values.

摘要

两种含有吗啉基团配体的铱(III)配合物被用于追踪细胞凋亡过程中线粒体的pH波动,因为它们的发射强度会随着pH值的升高而线性增加。

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