Lee Susan S, Burke James, Shen Jie, Almazan Alexandra, Orilla Werhner, Hughes Patrick, Zhang Jane, Li Huajiang, Struble Craig, Miller Paul E, Robinson Michael R
Allergan plc, Irvine, CA, USA.
Covance Laboratories Inc., Madison, WI, USA.
Vet Ophthalmol. 2018 Jul;21(4):376-381. doi: 10.1111/vop.12522. Epub 2018 Feb 19.
To determine the effect of a bimatoprost sustained-release intracameral implant (Bimatoprost SR) on episcleral venous pressure (EVP) in normal dogs.
Normotensive beagle dogs were randomized to receive Bimatoprost SR 30 μg (n = 7) or sham injection (needle insertion only, n = 7) in one eye on day 1. EVP was measured with an episcleral venomanometer through day 65. Episcleral aqueous outflow vessels were identified using fluorescence imaging following intracameral injection of indocyanine green in one additional animal. A separate cohort of dogs that had been trained for conscious intraocular pressure (IOP) measurements received Bimatoprost SR 30 μg (n = 8) in one eye; IOP was evaluated through day 66.
Baseline mean EVP was 10.0 mmHg in the Bimatoprost SR group and 10.4 mmHg in the sham group. Eyes treated with Bimatoprost SR exhibited a transient increase in mean EVP that peaked at day 8, followed by a decrease to levels below baseline. From day 29 to day 65, the change in mean EVP from baseline ranged from -2.4 to -3.9 mmHg (P < 0.05 vs. sham). Baseline mean IOP in eyes treated with Bimatoprost SR was 14.9 mmHg, and a steady IOP reduction was maintained through day 66. Bimatoprost SR-treated eyes exhibited a selective, sustained dilation of aqueous outflow vessels that was not observed in sham-treated eyes.
In normal dogs, Bimatoprost SR was associated with a transient increase in EVP followed by a sustained decrease. Changes in EVP were accompanied by a sustained dilation of aqueous outflow vessels.
确定比马前列素缓释前房内植入物（比马前列素SR）对正常犬巩膜静脉压（EVP）的影响。
血压正常的比格犬在第1天被随机分为单眼接受30μg比马前列素SR（n = 7）或假注射（仅针头插入，n = 7）。通过第65天使用巩膜静脉压力计测量EVP。在另外一只动物前房内注射吲哚菁绿后，使用荧光成像识别巩膜房水流出血管。另一组经过清醒眼压（IOP）测量训练的犬单眼接受30μg比马前列素SR（n = 8）；通过第66天评估IOP。
比马前列素SR组的基线平均EVP为10.0 mmHg，假手术组为10.4 mmHg。接受比马前列素SR治疗的眼睛平均EVP出现短暂升高，在第8天达到峰值，随后降至基线以下水平。从第29天到第65天，平均EVP相对于基线的变化范围为-2.4至-3.9 mmHg（与假手术组相比，P < 0.05）。接受比马前列素SR治疗的眼睛基线平均IOP为14.9 mmHg，并且在第66天之前IOP持续稳定降低。接受比马前列素SR治疗的眼睛表现出房水流出血管的选择性、持续性扩张，而在假手术组中未观察到。
在正常犬中，比马前列素SR与EVP短暂升高随后持续降低有关。EVP的变化伴随着房水流出血管的持续性扩张。
