黄精新异黄酮 H，一种具有细胞毒性的新异黄酮，来自黄精属植物。
Polygonatone H, a new homoisoflavanone with cytotoxicity from Hua.
机构信息
a Yunnan Agricultural University National & Local Joint Engineering Research Center on Gemplasm Utilization & Innovation of Chinese Medicinal Materials in Southwest China , Kunming , China.
b College of Resources and Environment , Yunnan Agricultural University , Kunming , China.
出版信息
Nat Prod Res. 2019 Jun;33(12):1727-1733. doi: 10.1080/14786419.2018.1434645. Epub 2018 Feb 19.
A new homoisoflavonoid, (3)-5,7-dihydroxy-6-methyl-3-(2'-hydroxy-4'-methoxybenzyl)-chroman-4-one (), namely polygonatone H, in addition to fourteen known homoisoflavones (-) were isolated from the rhizome of Hua. The structures were identified with the aid of 1D/2D NMR spectroscopic technologies. Compounds , , , , , , and were isolated from for the first time. Compound showed cytotoxicities to human cancer cell lines with IC values to comparable those of cisplatin.
一种新的异黄酮，（3）-5，7-二羟基-6-甲基-3-（2'-羟基-4'-甲氧基苄基）-色满-4-酮（），即 Polygonatone H，除了十四种已知的异黄酮（-）外，还从 的根茎中分离出来。结构是借助于 1D/2D NMR 光谱技术确定的。化合物、、、、、、和 是首次从 中分离出来的。化合物 对人癌细胞系显示出细胞毒性，IC 值与顺铂相当。
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