Lin Hongyuan, Wang Wenhui, Peng Mengqi, Kong Yifan, Zhang Xiaowei, Wei Xiaohong, Shang Hongcai
College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China.
Weifang Medical University, Weifang, 261000, China.
Chin Med. 2024 Jan 2;19(1):1. doi: 10.1186/s13020-023-00871-0.
Despite continued advances in prevention and treatment strategies, cardiovascular diseases (CVDs) remain the leading cause of death worldwide, and more effective therapeutic methods are urgently needed. Polygonatum is a traditional Chinese herbal medicine with a variety of pharmacological applications and biological activities, such as antioxidant activity, anti-inflammation, antibacterial effect, immune-enhancing effect, glucose regulation, lipid-lowering and anti-atherosclerotic effects, treatment of diabetes and anticancer effect. There has also been more and more evidence to support the cardioprotective effect of Polygonatum in recent years. However, up to now, there has been a lack of comprehensive studies on the active ingredients and their pharmacotoxicological effects related to cardiovascular diseases. Therefore, the main active components of Polygonatum (including Polysaccharides, Flavonoids, Saponins) and their biological activities were firstly reviewed in this paper. Furthermore, we summarized the pharmacological effects of Polygonatum's active components in preventing and treating CVDs, and its relevant toxicological investigations. Finally, we emphasize the potential of Polygonatum in the prevention and treatment of CVDs.
尽管在预防和治疗策略方面不断取得进展，但心血管疾病（CVDs）仍然是全球主要的死亡原因，因此迫切需要更有效的治疗方法。黄精是一种传统的中草药，具有多种药理应用和生物活性，如抗氧化活性、抗炎、抗菌作用、免疫增强作用、血糖调节、降脂和抗动脉粥样硬化作用、治疗糖尿病和抗癌作用。近年来，也有越来越多的证据支持黄精对心脏的保护作用。然而，到目前为止，尚未对与心血管疾病相关的活性成分及其药物毒理学作用进行全面研究。因此，本文首先综述了黄精的主要活性成分（包括多糖、黄酮类化合物、皂苷）及其生物活性。此外，我们总结了黄精活性成分在预防和治疗心血管疾病方面的药理作用及其相关的毒理学研究。最后，我们强调了黄精在预防和治疗心血管疾病方面的潜力。
Zotero 插件
