Liu Shuang, Jia Qiao-Jun, Peng Yi-Qing, Feng Ting-Hui, Hu Shu-Ting, Dong Juan-E, Liang Zong-Suo
College of Life Sciences, Northwest A & F University, Xi'an, China.
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Front Pharmacol. 2022 Feb 8;13:758501. doi: 10.3389/fphar.2022.758501. eCollection 2022.
Diabetes mellitus is a fast-growing disease with a major influence on people's quality of life. Oral hypoglycemic drugs and insulin are currently the main effective drugs in the treatment of diabetes, but chronic consumption of these drugs has certain side effects. Polysaccharides, saponins, flavonoids, and phenolics are the primary secondary metabolites isolated from the rhizomes of Redouté [Asparagaceae], Collett & Hemsl [Asparagaceae], or Hua [Asparagaceae], which have attracted much more attention owing to their unique therapeutic role in the treatment and prevention of diabetes. However, the research on the mechanism of these three spp. in diabetes has not been reviewed. This review provides a summary of the research progress of three spp. on diabetes and its complications, reveals the potential antidiabetic mechanism of three spp., and discusses the effect of different processed products of three spp. in treating diabetes, for the sake of a thorough understanding of its effects on the prevention and treatment of diabetes and diabetes complications.
糖尿病是一种快速发展的疾病，对人们的生活质量有重大影响。口服降糖药和胰岛素是目前治疗糖尿病的主要有效药物，但长期服用这些药物有一定的副作用。多糖、皂苷、黄酮类化合物和酚类是从天门冬科的红门冬属、肖菝葜属或华重楼属植物根茎中分离出的主要次生代谢产物，由于它们在糖尿病治疗和预防中具有独特的治疗作用而备受关注。然而，尚未对这三个属植物在糖尿病方面的作用机制进行综述。本综述总结了这三个属植物在糖尿病及其并发症方面的研究进展，揭示了这三个属植物潜在的抗糖尿病机制，并讨论了这三个属植物不同加工产品在治疗糖尿病方面的作用，以便全面了解其对糖尿病及其并发症防治的作用。
