Muir P D, Gunz F W
Pathology. 1979 Oct;11(4):597-606. doi: 10.3109/00313027909059039.
Eight cell lines established originally at the Queensland Institute of Medical Research from human malignant melanoma explants have been studied by means of cytogenetic techniques. All showed abnormalities characteristic for each individual line and consisting of marker chromosomes and of changes in ploidy due to the addition of extra copies of normal chromosomes. Repeat cultures of some lines after one or two years contained most of the markers which had characterized the original samples; additional chromosome abnormalities were also found. An anlysis of the break points concerned in the production of markers showed preferential involvement of chromosomes 1 and 5, with a prevalence of centromeric breaks on No. 1. These findings add further weight to the evidence suggesting that changes in chromosome 1 may be of special significance in the pathogenesis of some solid tumours.
昆士兰医学研究所最初从人类恶性黑色素瘤外植体建立的八个细胞系，已通过细胞遗传学技术进行了研究。所有细胞系都显示出每个个体细胞系特有的异常，包括标记染色体以及由于正常染色体额外拷贝的增加而导致的倍性变化。一些细胞系在一两年后的重复培养中包含了大多数表征原始样本的标记；还发现了其他染色体异常。对标记产生过程中相关断点的分析表明，1号和5号染色体优先受累，其中1号染色体着丝粒断裂更为普遍。这些发现进一步支持了以下证据，即1号染色体的变化可能在某些实体瘤的发病机制中具有特殊意义。
