de Lucca E J, Pathak S, Cheung M C
Department of Cell Biology, University of Texas System Cancer Center M.D. Anderson Hospital and Tumor Institute, Houston 77030.
Int J Cancer. 1988 Feb 15;41(2):297-304. doi: 10.1002/ijc.2910410222.
A cytogenetic study was done on a human malignant melanoma cell line and its 5 clones. Chromosome banding analysis indicated the presence of 7 "shared" markers (M) and 9 unique markers (m) that were present only in the clones. Chromosomes 1, 5, 9, 12, 17 and 21 were involved in M-markers and chromosomes 1, 2, 4, 6, 8, 9, 11, 16, 17, 18 and 21 were involved in m-marker formation. Both parental and clonal lines had near-triploid chromosome numbers. A number of M-markers were isochromosomes of the short (p) and long (q) arms of chromosome 1. Our cytogenetic data indicate that the parental line contained subpopulations of cells that were in different stages of karyotypic evolution.
对一种人类恶性黑色素瘤细胞系及其5个克隆进行了细胞遗传学研究。染色体带型分析表明存在7个“共享”标记（M）和9个仅存在于克隆中的独特标记（m）。1号、5号、9号、12号、17号和21号染色体参与了M标记的形成，1号、2号、4号、6号、8号、9号、11号、16号、17号、18号和21号染色体参与了m标记的形成。亲代系和克隆系的染色体数目均接近三倍体。许多M标记是1号染色体短臂（p）和长臂（q）的等臂染色体。我们的细胞遗传学数据表明，亲代系包含处于核型进化不同阶段的细胞亚群。
