阿尔茨海默病进程中的血浆淀粉样蛋白水平及其与中枢生物标志物的相关性。

Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers.

机构信息

Memory Resource and Research Centre of de Paris-Broca-Ile de France, Hopital Broca, APHP, Paris, France; EA 4468, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

出版信息

Alzheimers Dement. 2018 Jul;14(7):858-868. doi: 10.1016/j.jalz.2018.01.004. Epub 2018 Feb 17.

DOI:10.1016/j.jalz.2018.01.004

PMID:29458036

Abstract

INTRODUCTION

Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer's disease (AD) process yields conflicting results. The objective of the study was to assess plasma levels of Aβ and Aβ in amnestic mild cognitive impairment (MCI), nonamnestic MCI, and AD patients and to investigate relationships between peripheral and central biomarkers.

METHODS

One thousand forty participants (417 amnestic MCI, 122 nonamnestic MCI, and 501 AD) from the Biomarker of AmyLoïd pepTide and AlZheimer's diseAse Risk multicenter prospective study with cognition, plasma, cerebrospinal fluid (CSF), and magnetic resonance imaging assessments were included.

RESULTS

Plasma Aβ and Aβ were lower in AD (36.9 [11.7] and 263 [80] pg/mL) than in amnestic MCI (38.2 [11.9] and 269 [68] pg/mL) than in nonamnestic MCI (39.7 [10.5] and 272 [52] pg/mL), respectively (P = .01 for overall difference between groups for Aβ and P = .04 for Aβ). Globally, plasma Aβ correlated with age, Mini-Mental State Examination, and APOE ε4 allele. Plasma Aβ correlated with all CSF biomarkers in MCI but only with CSF Aβ in AD.

DISCUSSION

Plasma Aβ was associated with cognitive status and CSF biomarkers, suggesting the interest of plasma amyloid biomarkers for diagnosis purpose.

摘要

简介

血浆淀粉样蛋白 β（Aβ）对阿尔茨海默病（AD）进程的诊断相关性产生了相互矛盾的结果。本研究的目的是评估 AD 患者、遗忘型轻度认知障碍（MCI）患者和非遗忘型 MCI 患者的血浆 Aβ 和 Aβ 水平，并探讨外周和中枢生物标志物之间的关系。

方法

来自多中心前瞻性研究的 1040 名参与者（417 名遗忘型 MCI、122 名非遗忘型 MCI 和 501 名 AD），进行认知、血浆、脑脊液（CSF）和磁共振成像评估，纳入本研究。

结果

与遗忘型 MCI（38.2 [11.9] pg/mL 和 269 [68] pg/mL）相比，AD 患者的血浆 Aβ 和 Aβ 水平较低（36.9 [11.7] pg/mL 和 263 [80] pg/mL）（P <.01），与非遗忘型 MCI 相比，AD 患者的血浆 Aβ 和 Aβ 水平也较低（39.7 [10.5] pg/mL 和 272 [52] pg/mL）（P <.04）。总体而言，血浆 Aβ 与年龄、简易精神状态检查和 APOE ε4 等位基因相关。在 MCI 中，血浆 Aβ 与所有 CSF 生物标志物相关，但在 AD 中仅与 CSF Aβ 相关。