Zhu Heping, Jiang Jiannong, Wang Qiang, Zong Jun, Zhang Liang, Ma Tieliang, Xu Youjia, Zhang Leiyan
Department of Orthopedics, The Affiliated Yixing Hospital of Jiangsu University, Yixing, 214200, China.
Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
BMC Endocr Disord. 2018 Feb 20;18(1):11. doi: 10.1186/s12902-018-0230-x.
Many studies have reported associations between estrogen receptor (ER) gene polymorphisms and postmenopausal osteoporosis (PMOP) risk and bone mineral density (BMD), but the results are controversial. The aim of the present meta-analysis is to verify the association between ERα and ERβ gene polymorphisms and osteoporosis susceptibility and BMD in postmenopausal women.
PubMed, EMBASE, Web of Science, the Cochrane Library and China WeiPu Library were searched. OR and WMD with 95% CI were calculated to assess the association.
Overall, no significant association was observed between ERα XbaI, ERα PvuII and PMOP susceptibility in either overall, Caucasian or Asian populations. ERα G2014A was significantly associated with a decreased risk of PMOP in Caucasian populations. There was a significant association between ERβ RsaI and PMOP risk in both overall and Asian populations. Caucasian PMOP women with ERα XbaI XX and Xx genotypes had a higher LS Z value than women with xx genotype. ERα XbaI XX genotype was associated with increased FN BMD in overall and Caucasian populations, an increased FN Z value in Asians, and a decreased FN Z value in Caucasians. There was also a significant association between ERα XbaI Xx genotype and an increased FN Z value in either Asians or Caucasians. ERα PvuII PP genotype was associated with a low LS Z value in Caucasians and a low FN BMD and Z value in Asians. Pp genotype in PMOP women was significantly correlated with low LS BMD in overall populations, a low FN Z value in either overall, Caucasian or Asian populations.
Each ERα and ERβ gene polymorphism might have different impact on PMOP risk and BMD in various ethnicities.
许多研究报道了雌激素受体（ER）基因多态性与绝经后骨质疏松症（PMOP）风险及骨密度（BMD）之间的关联，但结果存在争议。本荟萃分析的目的是验证ERα和ERβ基因多态性与绝经后女性骨质疏松症易感性及骨密度之间的关联。
检索了PubMed、EMBASE、Web of Science、Cochrane图书馆和中国维普图书馆。计算了比值比（OR）和加权均数差（WMD）及其95%置信区间（CI）以评估关联。
总体而言，在总体人群、白种人群或亚洲人群中，未观察到ERα XbaI、ERα PvuII与PMOP易感性之间存在显著关联。在白种人群中，ERα G2014A与PMOP风险降低显著相关。在总体人群和亚洲人群中，ERβ RsaI与PMOP风险均存在显著关联。携带ERα XbaI XX和Xx基因型的白种PMOP女性的腰椎Z值高于携带xx基因型的女性。在总体人群和白种人群中，ERα XbaI XX基因型与股骨颈骨密度增加相关，在亚洲人群中与股骨颈Z值增加相关，在白种人群中与股骨颈Z值降低相关。在亚洲或白种人群中，ERα XbaI Xx基因型与股骨颈Z值增加也存在显著关联。在白种人群中，ERα PvuII PP基因型与低腰椎Z值相关，在亚洲人群中与低股骨颈骨密度和Z值相关。在总体人群中，PMOP女性的Pp基因型与低腰椎骨密度显著相关，在总体人群、白种人群或亚洲人群中与低股骨颈Z值相关。
ERα和ERβ基因的每种多态性可能对不同种族的PMOP风险和骨密度有不同影响。
