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成人注意缺陷多动障碍患者失眠与睡眠时间的关系:一项基于一般人群的研究结果。

The Association Between Insomnia and Sleep Duration in Adults With Attention-Deficit Hyperactivity Disorder: Results From a General Population Study.

机构信息

PsyQ Expertise Center Adult ADHD, The Hague, The Netherlands.

Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands.

出版信息

J Clin Sleep Med. 2018 Mar 15;14(3):349-357. doi: 10.5664/jcsm.6976.

Abstract

STUDY OBJECTIVES

Insomnia and short or long sleep duration are important comorbid conditions in adults with attention-deficit hyperactivity disorder (ADHD), but reports of the association vary. In a general population study, we evaluated the relationship between ADHD symptom severity, insomnia symptoms, and sleep duration in adults.

METHODS

Data were from the third wave of the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2; n = 4,618). ADHD symptom severity and symptom dimensions (hyperactivity and inattention) were assessed using the Adult ADHD Self-Report Scale screener. Self-reported insomnia symptoms (Insomnia Rating Scale; IRS) were defined as clinically relevant if IRS ≥ 9. Self-reported short sleep duration was defined as ≤ 6 hours, and long sleep duration as ≥ 10 hours.

RESULTS

Within the group with clinically relevant ADHD symptoms, 43% reported significant insomnia symptoms (odds ratio [OR] = 2.66, 95% confidence interval [CI] 1.74-4.07); 41% short sleep duration (relative risk ratio [RRR] = 1.94, 95% CI 1.31-2.85) and 6% long sleep (RRR = 5.87, 95% CI 1.97-17.45). Increased inattention symptoms were associated with IRS ≥ 9, short and long sleep duration in fully adjusted models (OR = 1.10, 95% CI 1.06-1.14; RRR = 1.06, 95% CI 1.02-1.09; RRR = 1.16, 95% CI 1.05-1.28, respectively). Increased hyperactivity symptoms were associated with IRS ≥ 9 (OR = 1.17, 95% CI 1.11-1.23) and short sleep duration (RRR = 1.12, 95% CI 1.05-1.19).

CONCLUSIONS

Both clinically significant ADHD symptoms and inattention and hyperactivity symptom dimensions were consistently associated with insomnia symptoms and altered sleep duration. These associations confirm that sleep disturbances should be assessed and given appropriate clinical attention in adults with ADHD.

摘要

研究目的

失眠和睡眠时间短或长是成人注意力缺陷多动障碍(ADHD)的重要合并症,但相关报告存在差异。在一项普通人群研究中,我们评估了 ADHD 症状严重程度、失眠症状和成人睡眠时间之间的关系。

方法

数据来自荷兰心理健康调查和发病率研究第三波(NEMESIS-2;n=4618)。使用成人 ADHD 自我报告量表筛查器评估 ADHD 症状严重程度和症状维度(多动和注意力不集中)。如果 IRS≥9,则将自我报告的失眠症状(失眠评定量表;IRS)定义为具有临床意义。自我报告的短睡眠时间定义为≤6 小时,长睡眠时间定义为≥10 小时。

结果

在有临床意义的 ADHD 症状组中,43%的人报告有明显的失眠症状(优势比[OR] = 2.66,95%置信区间[CI] 1.74-4.07);41%的人有短睡眠时间(相对风险比[RRR] = 1.94,95%置信区间[CI] 1.31-2.85)和 6%的人有长睡眠时间(RRR = 5.87,95%置信区间[CI] 1.97-17.45)。在完全调整模型中,注意力不集中症状增加与 IRS≥9、短睡眠时间和长睡眠时间相关(OR=1.10,95%CI 1.06-1.14;RRR=1.06,95%CI 1.02-1.09;RRR=1.16,95%CI 1.05-1.28)。多动症状增加与 IRS≥9(OR=1.17,95%CI 1.11-1.23)和短睡眠时间相关(RRR=1.12,95%CI 1.05-1.19)。

结论

有临床意义的 ADHD 症状以及注意力不集中和多动症状维度均与失眠症状和睡眠时间改变一致相关。这些关联证实,在 ADHD 成人中,应评估睡眠障碍并给予适当的临床关注。

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