一种使用手机内置相机闪光灯和环境光的双模手机显微镜。

Orth A, Wilson E R, Thompson J G, Gibson B C

ARC Centre of Excellence for Nanoscale BioPhotonics, School of Science, RMIT University, Melbourne, Australia.

ARC Centre of Excellence for Nanoscale BioPhotonics, Robinson Research Institute, School of Medicine, The University of Adelaide, Adelaide, Australia.

Sci Rep. 2018 Feb 19;8(1):3298. doi: 10.1038/s41598-018-21543-2.

Mobile phone microscopes are a natural platform for point-of-care imaging, but current solutions require an externally powered illumination source, thereby adding bulk and cost. We present a mobile phone microscope that uses the internal flash or sunlight as the illumination source, thereby reducing complexity whilst maintaining functionality and performance. The microscope is capable of both brightfield and darkfield imaging modes, enabling microscopic visualisation of samples ranging from plant to mammalian cells. We describe the microscope design principles, assembly process, and demonstrate its imaging capabilities through the visualisation of unlabelled cell nuclei to observing the motility of cattle sperm and zooplankton.

手机显微镜是即时医疗成像的天然平台，但目前的解决方案需要外部供电的照明源，从而增加了体积和成本。我们展示了一种使用手机内置闪光灯或阳光作为照明源的手机显微镜，从而在保持功能和性能的同时降低了复杂性。该显微镜具备明场和暗场成像模式，能够对从植物细胞到哺乳动物细胞等各种样本进行微观可视化观察。我们描述了显微镜的设计原理、组装过程，并通过对未标记细胞核的可视化观察、牛精子和浮游动物运动性的观察，展示了其成像能力。