折叠显微镜：基于折纸的纸质显微镜。

Cybulski James S, Clements James, Prakash Manu

Department of Mechanical Engineering, Stanford University, Stanford, California, United States of America.

Department of Bioengineering, Stanford University, Stanford, California, United States of America.

PLoS One. 2014 Jun 18;9(6):e98781. doi: 10.1371/journal.pone.0098781. eCollection 2014.

Here we describe an ultra-low-cost origami-based approach for large-scale manufacturing of microscopes, specifically demonstrating brightfield, darkfield, and fluorescence microscopes. Merging principles of optical design with origami enables high-volume fabrication of microscopes from 2D media. Flexure mechanisms created via folding enable a flat compact design. Structural loops in folded paper provide kinematic constraints as a means for passive self-alignment. This light, rugged instrument can survive harsh field conditions while providing a diversity of imaging capabilities, thus serving wide-ranging applications for cost-effective, portable microscopes in science and education.

在此，我们描述了一种基于折纸的超低成本方法，用于大规模制造显微镜，具体展示了明场、暗场和荧光显微镜。将光学设计原理与折纸相结合，能够从二维材料大量制造显微镜。通过折叠形成的挠曲机构实现了扁平紧凑的设计。折叠纸张中的结构环提供运动学约束，作为被动自对准的一种手段。这种轻便、坚固的仪器能够在恶劣的野外条件下使用，同时具备多种成像能力，从而为科学和教育领域中经济高效的便携式显微镜提供广泛的应用。