在加纳使用手机搭载的Foldscope和反向镜头CellScope诊断埃及血吸虫感染
Diagnosis of Schistosoma haematobium infection with a mobile phone-mounted Foldscope and a reversed-lens CellScope in Ghana.
作者信息
Ephraim Richard K D, Duah Evans, Cybulski James S, Prakash Manu, D'Ambrosio Michael V, Fletcher Daniel A, Keiser Jennifer, Andrews Jason R, Bogoch Isaac I
机构信息
Division of Medical Laboratory Technology, University of Cape Coast, Cape Coast, Ghana; Department of Mechanical Engineering, Stanford University, Stanford, California; Department of Bioengineering, Stanford University, Stanford, California; Department of Bioengineering, University of California, Berkeley, Berkeley, California; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California; Divisions of Internal Medicine and Infectious Diseases, University Health Network, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Division of Medical Laboratory Technology, University of Cape Coast, Cape Coast, Ghana; Department of Mechanical Engineering, Stanford University, Stanford, California; Department of Bioengineering, Stanford University, Stanford, California; Department of Bioengineering, University of California, Berkeley, Berkeley, California; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California; Divisions of Internal Medicine and Infectious Diseases, University Health Network, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada
出版信息
Am J Trop Med Hyg. 2015 Jun;92(6):1253-6. doi: 10.4269/ajtmh.14-0741. Epub 2015 Apr 27.
We evaluated two novel, portable microscopes and locally acquired, single-ply, paper towels as filter paper for the diagnosis of Schistosoma haematobium infection. The mobile phone-mounted Foldscope and reversed-lens CellScope had sensitivities of 55.9% and 67.6%, and specificities of 93.3% and 100.0%, respectively, compared with conventional light microscopy for diagnosing S. haematobium infection. With conventional light microscopy, urine filtration using single-ply paper towels as filter paper showed a sensitivity of 67.6% and specificity of 80.0% compared with centrifugation for the diagnosis of S. haematobium infection. With future improvements to diagnostic sensitivity, newer generation handheld and mobile phone microscopes may be valuable tools for global health applications.
我们评估了两款新型便携式显微镜以及在当地购置的单层纸巾作为滤纸，用于诊断埃及血吸虫感染。与用于诊断埃及血吸虫感染的传统光学显微镜相比，安装在手机上的折叠显微镜（Foldscope）和反向透镜细胞显微镜（CellScope）的灵敏度分别为55.9%和67.6%，特异性分别为93.3%和100.0%。在诊断埃及血吸虫感染时，与离心法相比，使用单层纸巾作为滤纸进行尿液过滤，传统光学显微镜显示的灵敏度为67.6%，特异性为80.0%。随着诊断灵敏度的进一步提高，新一代手持和手机显微镜可能会成为全球卫生应用中的宝贵工具。
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