Tanaka H, Shindo M, Gutkowska J, Kinoshita A, Urata H, Ikeda M, Arakawa K
Life Sci. 1986 Nov 3;39(18):1685-93. doi: 10.1016/0024-3205(86)90166-9.
The effect of acute exercise on plasma immunoreactive-atrial natriuretic factor (IR-ANF) was studied in 5 healthy young males subjected to graded exercise on a bicycle ergometer at four different work intensities (approx. 30, 50, 70, and 90% VO2max respectively). Except for the final exercise period, which was continued until exhaustion, all the others were of 30 min duration. Venous blood samples were obtained in the last 2 min of each exercise period. The plasma IR-ANF response to exercise was similar to that of heart rate and systolic blood pressure in that mild exercise in the first stage (corresponding to approx. 30% VO2 max) caused a striking increase of plasma IR-ANF concentrations with a further augmentation in the next stages and a levelling off at exhaustion. Plasma arginine-vasopressin (AVP) and aldosterone (ALDO) rose significantly only in the last two stages, and the highest concentrations were observed at exhaustion. In conclusion, acute exercise stimulates ANF secretion in proportion to the intensity of exercise, while concomitant increases in plasma AVP and ALDO occur only when the work load exceeds the blood lactate (BLA) threshold.
在5名健康年轻男性中研究了急性运动对血浆免疫反应性心房钠尿肽（IR-ANF）的影响，这些男性在自行车测力计上以四种不同的工作强度（分别约为最大摄氧量的30%、50%、70%和90%）进行分级运动。除了最后一个运动期持续到 exhaustion 外，其他所有运动期均持续30分钟。在每个运动期的最后2分钟采集静脉血样。血浆IR-ANF对运动的反应与心率和收缩压相似，即第一阶段的轻度运动（对应于约30%最大摄氧量）导致血浆IR-ANF浓度显著升高，在下一阶段进一步升高，并在 exhaustion 时趋于平稳。血浆精氨酸加压素（AVP）和醛固酮（ALDO）仅在最后两个阶段显著升高，且在 exhaustion 时观察到最高浓度。总之，急性运动按运动强度比例刺激ANF分泌，而仅当工作负荷超过血乳酸（BLA）阈值时，血浆AVP和ALDO才会同时升高。
