Saito Y, Nakao K, Sugawara A, Nishimura K, Sakamoto M, Morii N, Yamada T, Itoh H, Shiono S, Kuriyama T
Department of Medicine, Kyoto University School of Medicine, Japan.
Acta Endocrinol (Copenh). 1987 Sep;116(1):59-65. doi: 10.1530/acta.0.1160059.
The plasma concentration of atrial natriuretic polypeptide was measured in eight healthy men during two grades of exercise performed in the supine position on a bicycle ergometer. The plasma concentration of atrial natriuretic polypeptide slightly increased during the first exercise test with 20% of the maximal oxygen uptake and it approximately doubled during the second exercise with 40% of the maximal oxygen uptake (from 15.5 +/- 5.5 (mean +/- SD) pmol/l to 31.8 +/- 10.7 pmol/l). The increase in the plasma level of atrial natriuretic polypeptide in the second exercise was significantly greater than that in the first one. The plasma norepinephrine level and plasma renin activity showed significant increases during the second exercise test. Heart rate and systolic blood pressure also increased in response to the graded exercise. The increase in the plasma concentration of atrial natriuretic polypeptide during exercise was significantly correlated with the increase in heart rate, systolic blood pressure, and the plasma norepinephrine concentration (r = 0.75, r = 0.71 and r = 0.51, respectively). These results indicate that the plasma concentration of atrial natriuretic polypeptide increases in response to the intensity of a workload, and suggest that exercise is a useful test to evaluate the releasing function of atrial natriuretic polypeptide in the heart.
在八名健康男性于卧式自行车测力计上进行两个等级的运动期间，测量了心房利钠多肽的血浆浓度。在第一次运动测试（最大摄氧量的20%）期间，心房利钠多肽的血浆浓度略有增加，而在第二次运动（最大摄氧量的40%）期间，其浓度大约翻倍（从15.5±5.5（平均值±标准差）pmol/l增至31.8±10.7 pmol/l）。第二次运动时心房利钠多肽血浆水平的升高显著大于第一次。在第二次运动测试期间，血浆去甲肾上腺素水平和血浆肾素活性显著升高。心率和收缩压也随着分级运动而增加。运动期间心房利钠多肽血浆浓度的升高与心率、收缩压以及血浆去甲肾上腺素浓度的升高显著相关（相关系数分别为r = 0.75、r = 0.71和r = 0.51）。这些结果表明，心房利钠多肽的血浆浓度随着工作负荷强度的增加而升高，并提示运动是评估心脏中心房利钠多肽释放功能的一项有用测试。
