Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China.
Immunochina Pharmaceuticals Co. Ltd., Beijing, China.
Crit Rev Eukaryot Gene Expr. 2020;30(5):427-442. doi: 10.1615/CritRevEukaryotGeneExpr.2020035775.
Mammalian STE20-like protein kinases (MST), including MST1, MST2, MST3, and MST4, belong to the germinal center kinase (GCK) family. Kinase MST1/2 is an important component of the Hippo pathway in regulating cell proliferation, tissue homeostasis, and organ development. Recent studies have shown that Hippo kinase MST1/2 plays a crucial role in immune-associated diseases, which has attracted extensive attention of researchers. This review summarizes recent research on Hippo kinases MST1/2 in regulating the function of immune cells in innate and adaptive immune systems, and also includes its regulatory role and significance in cancer, infection, and autoimmune diseases.
哺乳动物 STE20 样蛋白激酶（MST），包括 MST1、MST2、MST3 和 MST4，属于生发中心激酶（GCK）家族。激酶 MST1/2 是 Hippo 通路中调节细胞增殖、组织平衡和器官发育的重要组成部分。最近的研究表明，Hippo 激酶 MST1/2 在免疫相关疾病中起着至关重要的作用，这引起了研究人员的广泛关注。本综述总结了 Hippo 激酶 MST1/2 在调节先天和适应性免疫系统中免疫细胞功能方面的最新研究，还包括其在癌症、感染和自身免疫性疾病中的调节作用和意义。
