Ozer C, Caglar Aytac P, Goren M R, Toksoz S, Gul U, Turunc T
Department of Urology, Adana Dr. Turgut Noyan Medical and Research Center, Baskent University School of Medicine, Adana, Turkey.
Department of Obstetrics and Gynecology, Adana Dr. Turgut Noyan Medical and Research Center, Baskent University School of Medicine, Adana, Turkey.
Andrologia. 2018 Feb 20. doi: 10.1111/and.12983.
Klinefelter syndrome is the most frequent chromosomal abnormality in patients with nonobstructive azoospermia. The development of advanced assisted reproductive techniques, such as testicular sperm extraction and intracytoplasmic sperm injection, has provided the possibility of biological fathering in nonobstructive azoospermic patients with Klinefelter syndrome. We aimed to evaluate our sperm retrieval rate by microdissection testicular sperm extraction and to analyse the intracytoplasmic sperm injection outcomes in these patients. Medical records of 110 nonobstructive azoospermic patients with Klinefelter syndrome were retrospectively reviewed. We found that the sperm retrieval rate by microdissection testicular sperm extraction is lower than published reports on other types of secretory azoospermia. The statistical analyses yielded that age, FSH and testosterone levels as predictive factors for successful sperm retrieval.
克兰费尔特综合征是无梗阻性无精子症患者中最常见的染色体异常。先进辅助生殖技术的发展，如睾丸精子提取术和卵胞浆内单精子注射技术，为患有克兰费尔特综合征的无梗阻性无精子症患者实现生物学意义上的生育提供了可能。我们旨在评估显微切割睾丸精子提取术的精子获取率，并分析这些患者的卵胞浆内单精子注射结果。我们回顾性分析了110例患有克兰费尔特综合征的无梗阻性无精子症患者的病历。我们发现，显微切割睾丸精子提取术的精子获取率低于其他类型分泌性无精子症的已发表报告。统计分析得出年龄、促卵泡生成素和睾酮水平是精子获取成功的预测因素。
