University of Adelaide Medical School, Adelaide, SA, Australia.
Freemasons Foundation Centre for Men's Health, Adelaide, SA, Australia.
BJU Int. 2018 May;121 Suppl 3:9-21. doi: 10.1111/bju.14173. Epub 2018 Mar 26.
Emerging data have linked certain features of clinical prostate cancer (PCa) to obesity and, more specifically, increased adiposity. Whereas the large number of clinical studies and meta-analyses that have explored the associations between PCa and obesity have shown considerable variability, particularly in relation to prostate cancer risk, there is an accumulating weight of evidence consistently linking obesity to greater aggressiveness of disease. In probing this association mechanistically, it has been posited that peri-prostatic adipose tissue (PPAT), a significant component of the prostate microenvironment, may be a critical source of fatty acids and other mitogens and thereby influences PCa pathogenesis and progression. Notably, several recent studies have identified secreted factors from both PPAT and PCa that potentially mediate the two-way communication between these intimately linked tissues. In the present review, we summarize the available literature regarding the relationship between PPAT and PCa, including the potential biological mediators of that relationship, and explore emerging areas of interest for future research endeavours.
新出现的数据将临床前列腺癌 (PCa) 的某些特征与肥胖联系起来，更具体地说，与肥胖有关。虽然大量探讨 PCa 与肥胖之间关联的临床研究和荟萃分析显示存在相当大的可变性，尤其是与前列腺癌风险有关，但越来越多的证据一致表明肥胖与疾病的侵袭性更强有关。在从机制上探讨这种关联时，有人假设前列腺周围脂肪组织 (PPAT) 是前列腺微环境的重要组成部分，可能是脂肪酸和其他有丝分裂原的重要来源，从而影响 PCa 的发病机制和进展。值得注意的是，最近的几项研究已经确定了来自 PPAT 和 PCa 的分泌因子，这些因子可能介导这两种密切相关的组织之间的双向通讯。在本综述中，我们总结了关于 PPAT 和 PCa 之间关系的现有文献，包括这种关系的潜在生物学介质，并探讨了未来研究工作的新兴兴趣领域。
