University of Pittsburgh.
University of California, Berkeley.
J Res Adolesc. 2018 Mar;28(1):87-102. doi: 10.1111/jora.12360.
Research suggests that altered emotion processing may be one important pathway linking social risk factors and depressive symptoms. We examined the extent to which neural response to negatively valenced social information might help to account for the relationship between social risk and depressive symptoms in youth. Forty-nine youth were scanned while identifying the emotional valence of words that connoted social status. They also completed questionnaires assessing self-reported social risk factors and depressive symptoms. Mediation analysis revealed that reduced dorsolateral prefrontal cortex activity in response to negative social status words explained the positive association between social risk and depressive symptoms. These findings suggest that social risk factors present during adolescence may contribute to depressive symptoms by influencing the neural substrates of emotion processing.
研究表明，情绪处理的改变可能是连接社会风险因素和抑郁症状的一个重要途径。我们研究了神经对负面社会信息的反应在多大程度上可以解释青少年中社会风险和抑郁症状之间的关系。49 名青少年在识别表示社会地位的词语的情绪效价时进行了扫描。他们还完成了评估自我报告的社会风险因素和抑郁症状的问卷。中介分析显示，对负面社会地位词语的背外侧前额叶皮层活动减少，解释了社会风险与抑郁症状之间的正相关关系。这些发现表明，青少年时期存在的社会风险因素可能通过影响情绪处理的神经基础，导致抑郁症状。
