Silk Jennifer S, Lee Kyung Hwa, Kerestes Rebecca, Griffith Julianne M, Dahl Ronald E, Ladouceur Cecile D
Department of Psychology, University of Pittsburgh, United States; Department of Psychiatry, University of Pittsburgh School of Medicine, United States.
Department of Psychology, University of Pittsburgh, United States.
Dev Cogn Neurosci. 2017 Dec;28:1-11. doi: 10.1016/j.dcn.2017.09.005. Epub 2017 Sep 23.
Concerns about social status are ubiquitous during adolescence, with information about social status often conveyed in text formats. Depressed adolescents may show alterations in the functioning of neural systems supporting processing of social status information. We examined whether depressed youth exhibited altered neural activation to social status words in temporal and prefrontal cortical regions thought to be involved in social cognitive processing, and whether this response was associated with development. Forty-nine adolescents (ages 10-18; 35 female), including 20 with major depressive disorder and 29 controls, were scanned while identifying the valence of words that connoted positive and negative social status. Results indicated that depressed youth showed reduced late activation to social status (vs neutral) words in the superior temporal cortex (STC) and medial prefrontal cortex (MPFC); whereas healthy youth did not show any significant differences between word types. Depressed youth also showed reduced late activation in the dorsolateral prefrontal cortex and fusiform gyrus to negative (vs positive) social status words; whereas healthy youth showed the opposite pattern. Finally, age was positively associated with MPFC activation to social status words. Findings suggest that hypoactivation in the "social cognitive brain network" might be implicated in altered interpersonal functioning in adolescent depression.
在青春期，对社会地位的担忧无处不在，有关社会地位的信息通常以文本形式传达。抑郁的青少年可能在支持社会地位信息处理的神经系统功能方面表现出改变。我们研究了抑郁的青少年在被认为参与社会认知处理的颞叶和前额叶皮质区域对社会地位词汇的神经激活是否发生改变，以及这种反应是否与发育有关。49名青少年（年龄10 - 18岁；35名女性），包括20名重度抑郁症患者和29名对照组，在识别表示积极和消极社会地位的词汇的效价时接受了扫描。结果表明，抑郁的青少年在颞上叶皮质（STC）和内侧前额叶皮质（MPFC）对社会地位（与中性）词汇的晚期激活减少；而健康青少年在词汇类型之间未显示出任何显著差异。抑郁的青少年在背外侧前额叶皮质和梭状回对消极（与积极）社会地位词汇的晚期激活也减少；而健康青少年表现出相反的模式。最后，年龄与MPFC对社会地位词汇的激活呈正相关。研究结果表明，“社会认知脑网络”的激活不足可能与青少年抑郁症患者人际功能的改变有关。
