Stringer Thomas, Nagler Arielle, Orlow Seth J, Oza Vikash S
a The Ronald O. Perelman Department of Dermatology , NYU School of Medicine , New York , NY , USA.
b Department of Pediatrics , NYU School of Medicine , New York , NY , USA.
J Dermatolog Treat. 2018 Nov;29(7):688-693. doi: 10.1080/09546634.2018.1442552. Epub 2018 Feb 25.
Washing and over-the-counter cleansers are common interventions in acne vulgaris (AV), but the clinical evidence for their benefit is poorly understood. This systematic review presents clinical studies of washing and cleanser efficacy in acne vulgaris to guide treatment recommendations of dermatologists.
We surveyed English-language articles indexed in MEDLINE (1951-March 2017) and EMBASE (1974-March 2017). Articles were required to be prospective studies of a single over-the-counter cleanser or washing intervention in AV with an objective AV outcome measurement published in a peer-reviewed journal.
Fourteen prospective studies representing 671 participants were included in this review. Modalities investigated included face washing frequency, true soap/syndet cleansing bars, antiseptic cleansers, alpha and beta-hydroxy (i.e. salicylic) acid cleansers, and several proprietary formulations. Given the low number of well-performed clinical studies of cleansers and washing, it is difficult to formulate reliable recommendations. We hope that our findings highlight the necessity of further investigation in this area.
洗脸和使用非处方洁面产品是寻常痤疮（AV）常见的干预措施，但对其益处的临床证据了解甚少。本系统评价展示了关于寻常痤疮中洗脸和洁面产品功效的临床研究，以指导皮肤科医生的治疗建议。
我们检索了MEDLINE（1951年 - 2017年3月）和EMBASE（1974年 - 2017年3月）中收录的英文文章。文章需为关于单一非处方洁面产品或在寻常痤疮中洗脸干预措施的前瞻性研究，并在同行评审期刊上发表了客观的寻常痤疮结局测量结果。
本评价纳入了14项前瞻性研究，共671名参与者。研究的方式包括洗脸频率、真正的肥皂/合成洗涤剂洁面皂、抗菌洁面产品、α和β - 羟基（即水杨酸）酸洁面产品以及几种专利配方。鉴于洁面产品和洗脸的高质量临床研究数量较少，难以制定可靠的建议。我们希望我们的研究结果突出了该领域进一步研究的必要性。
