Xia Yunqiu, Lyu Yansi, Yang Jiahong, He Xiaofeng, Yi Yi, Liu Jingjing, Zhu Zailing, Du Zheng, Chen Yuchao, Ai Yunfei
Department of Dermatology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Department of Dermatology, Shenzhen University General Hospital, Shenzhen, China.
J Cosmet Dermatol. 2025 Jul;24(7):e70350. doi: 10.1111/jocd.70350.
Currently, many studies are exploring the effects of cleansers containing petrolatum and fatty acids on skin condition, but no research has yet investigated the impact of cleansers containing ceramides on skin condition.
Therefore, this study aims to explore whether a ceramide-containing glycinate-based cleanser can improve the skin conditions of oily skin and skin post-intense pulsed light (IPL) treatments, with a particular focus on the skin barrier.
In this study, 88 volunteers were recruited and divided into two groups. Group 1 (n = 44, oily skin) used ceramide-containing cleansers for 28 days, with subsequent assessment of skin hydration, TEWL (transepidermal water loss), sebum content, and pore count. Group 2 (n = 44) received IPL treatment prior to using the same cleansers, followed by evaluation of redness and self-reported symptoms.
The experimental results demonstrated that in Group 1, after 28 days of product application, skin hydration increased by 47.37%, TEWL decreased by 13.42%, pore number was reduced by 6.92%, and sebum content showed a 79.18% reduction. For Group 2, comparative analysis revealed that following the use of ceramide-containing cleansers after IPL treatment, skin redness significantly decreased by 14.62% compared to post-IPL measurements, with concurrent notable improvements in all self-reported symptoms, including itching and tightness.
Overall, a ceramide-containing glycinate-based cleanser can effectively control sebum secretion, reduce pore size, and repair the skin barrier in oily skin. Additionally, it can help reduce redness in IPL-treated skin. For dermatologists and consumers, this formulation represents a promising option for people undergoing IPL procedures, combining cleansing with barrier repair to minimize post-treatment downtime.
目前，许多研究正在探索含凡士林和脂肪酸的洁面产品对皮肤状况的影响，但尚无研究调查含神经酰胺的洁面产品对皮肤状况的影响。
因此，本研究旨在探讨含神经酰胺的甘氨酸盐基洁面产品能否改善油性皮肤以及强脉冲光（IPL）治疗后皮肤的状况，尤其关注皮肤屏障。
本研究招募了88名志愿者并将其分为两组。第1组（n = 44，油性皮肤）使用含神经酰胺的洁面产品28天，随后评估皮肤水合作用、经表皮水分流失（TEWL）、皮脂含量和毛孔数量。第2组（n = 44）在使用相同洁面产品之前接受IPL治疗，然后评估皮肤发红情况和自我报告的症状。
实验结果表明，在第1组中，产品使用28天后，皮肤水合作用增加了47.37%，TEWL降低了13.42%，毛孔数量减少了6.92%，皮脂含量降低了79.18%。对于第2组，对比分析显示，IPL治疗后使用含神经酰胺的洁面产品后，与IPL治疗后测量结果相比，皮肤发红显著降低了14.62%，同时所有自我报告的症状，包括瘙痒和紧绷感都有明显改善。
总体而言，含神经酰胺的甘氨酸盐基洁面产品可以有效控制皮脂分泌，缩小毛孔大小，并修复油性皮肤的皮肤屏障。此外，它有助于减轻IPL治疗后皮肤的发红。对于皮肤科医生和消费者来说，这种配方对于接受IPL治疗的人来说是一个有前景的选择，它将清洁与屏障修复相结合，以尽量减少治疗后的恢复时间。
