Emerg Infect Dis. 2018 Mar;24(3):425-431. doi: 10.3201/eid2403.171258.
Histoplasmosis is one of the most common mycoses endemic to the United States, but it was reportable in only 10 states during 2016, when a national case definition was approved. To better characterize the epidemiologic features of histoplasmosis, we analyzed deidentified surveillance data for 2011-2014 from the following 12 states: Alabama, Arkansas, Delaware, Illinois, Indiana, Kentucky, Michigan, Minnesota, Mississippi, Nebraska, Pennsylvania, and Wisconsin. We examined epidemiologic and laboratory features and calculated state-specific annual and county-specific mean annual incidence rates. A total of 3,409 cases were reported. Median patient age was 49 (interquartile range 33-61) years, 2,079 (61%) patients were male, 1,273 (57%) patients were hospitalized, and 76 (7%) patients died. Incidence rates varied markedly between and within states. The high hospitalization rate suggests that histoplasmosis surveillance underestimates the true number of cases. Improved surveillance standardization and surveillance by additional states would provide more comprehensive knowledge of histoplasmosis in the United States.
组织胞浆菌病是美国最常见的地方性真菌病之一，但在 2016 年国家病例定义批准后，只有 10 个州报告了该病。为了更好地描述组织胞浆菌病的流行病学特征，我们分析了来自以下 12 个州的 2011-2014 年的匿名监测数据：阿拉巴马州、阿肯色州、特拉华州、伊利诺伊州、印第安纳州、肯塔基州、密歇根州、明尼苏达州、密西西比州、内布拉斯加州、宾夕法尼亚州和威斯康星州。我们检查了流行病学和实验室特征，并计算了各州的年度和各县的平均年度发病率。共报告了 3409 例病例。患者的中位年龄为 49 岁（四分位距 33-61 岁），2079 例（61%）为男性，1273 例（57%）住院，76 例（7%）死亡。发病率在各州之间和各州内差异显著。高住院率表明组织胞浆菌病监测低估了真实病例数。改进监测标准化和增加其他州的监测将提供更全面的美国组织胞浆菌病知识。
