Emerg Infect Dis. 2018 Mar;24(3):478-484. doi: 10.3201/eid2403.171718.
Of patients with multidrug-resistant tuberculosis (MDR TB), <50% complete treatment. Most treatment failures for patients with MDR TB are due to death during TB treatment. We sought to determine the proportion of deaths during MDR TB treatment attributable to TB itself. We used a structured verbal autopsy tool to interview family members of patients who died during MDR TB treatment in India during January-December 2016. A committee triangulated information from verbal autopsy, death certificate, or other medical records available with the family members to ascertain the underlying cause of death. For 66% of patient deaths (47/71), TB was the underlying cause of death. We assigned TB as the underlying cause of death for an additional 6 patients who died of suicide and 2 of pulmonary embolism. Deaths during TB treatment signify program failure; accurately determining the cause of death is the first step to designing appropriate, timely interventions to prevent premature deaths.
在患有耐多药结核病（MDR-TB）的患者中，<50%完成了治疗。大多数 MDR-TB 患者的治疗失败是由于在结核病治疗期间死亡。我们试图确定 MDR-TB 治疗期间死亡的比例归因于结核病本身。我们使用结构化的口述尸检工具，采访了 2016 年 1 月至 12 月期间在印度死于 MDR-TB 治疗的患者的家属。一个委员会从口述尸检、死亡证明或与家属可用的其他医疗记录中收集信息，以确定死亡的根本原因。对于 66%的患者死亡（47/71），结核病是死亡的根本原因。我们还将另外 6 名自杀死亡和 2 名死于肺栓塞的患者的死亡归因于结核病。结核病治疗期间的死亡标志着项目失败；准确确定死亡原因是设计适当、及时的干预措施以防止过早死亡的第一步。
