Xiao Jingjie, Cain Angelina, Purcell Sarah A, Ormsbee Michael J, Contreras Robert J, Kim Jeong-Su, Thornberry Robert, Springs Dawn, Gonzalez M Cristina, Prado Carla M
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada; Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, Florida State University, Tallahassee, FL, USA.
Tallhassee Memorial Bariatric Center, Tallahassee Memorial Hospital, Tallahassee, FL, USA.
Clin Nutr ESPEN. 2018 Feb;23:79-83. doi: 10.1016/j.clnesp.2017.12.004. Epub 2017 Dec 27.
To investigate the prevalence of sarcopenic obesity (SO) and its association with health outcomes in patients seeking weight loss treatment from a bariatric center.
In this retrospective study, patients [≥18 years old, body mass index (BMI) ≥30 kg/m] from the Tallahassee Memorial Bariatric Center and with baseline body composition assessment by bioelectrical impedance analysis were included. Fat mass index (FMI = fat mass/height) and fat-free mass index (FFMI = fat free mass/height) were calculated. SO was defined by a FMI/FFMI ratio greater than the 95 percentile of sex, BMI and ethnicity specific population-representative references. Medical records were reviewed for biochemical and comorbidity measures.
One hundred and forty-four patients (∼69% females, mean age 55.6 years, mean BMI 46.6 kg/m) were included. Patients' FMI/FFMI ratios ranged from 0.35 to 1.60 kg/m across body weight spectrum, with 51% having SO. Blood pressure, fasting glucose, triglycerides, HDL or LDL were not different between patients with and without SO. However, the prevalence of high cholesterol, asthma, alcoholism and hernia were higher in patients with SO. SO was the strongest univariate predictor of high cholesterol (OR = 2.08, 95% CI 1.07-4.04) and asthma (OR = 2.77, 95% CI = 1.12-6.83).
SO was prevalent and associated with adverse health outcomes, beyond that captured by anthropometric measures in the present study.
调查在一家减肥中心寻求减肥治疗的患者中肌肉减少性肥胖（SO）的患病率及其与健康结局的关联。
在这项回顾性研究中，纳入了来自塔拉哈西纪念减肥中心的患者[年龄≥18岁，体重指数（BMI）≥30 kg/m²]，并通过生物电阻抗分析进行了基线身体成分评估。计算脂肪量指数（FMI = 脂肪量/身高）和去脂体重指数（FFMI = 去脂体重/身高）。SO的定义为FMI/FFMI比值大于按性别、BMI和种族划分的特定人群代表性参考值的第95百分位数。查阅病历以获取生化指标和合并症信息。
共纳入144例患者（约69%为女性，平均年龄55.6岁，平均BMI为46.6 kg/m²）。患者的FMI/FFMI比值在整个体重范围内为0.35至1.60 kg/m²，其中51%患有SO。有SO和无SO的患者之间，血压、空腹血糖、甘油三酯、高密度脂蛋白或低密度脂蛋白没有差异。然而，SO患者中高胆固醇、哮喘、酗酒和疝气的患病率更高。SO是高胆固醇（OR = 2.08，95%CI 1.07 - 4.04）和哮喘（OR = 2.77，95%CI = 1.12 - 6.83）最强的单因素预测指标。
在本研究中，SO普遍存在且与不良健康结局相关，超出了人体测量指标所反映的范围。
