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[高压氧对大鼠不同组织线粒体质子ATP酶活性的影响]

[Effect of hyperbaric oxygenation on proton ATPase activity in mitochondria of various rat tissues].

作者信息

Gabibov M M

出版信息

Ukr Biokhim Zh (1978). 1986 Sep-Oct;58(5):81-3.

PMID:2946097
Abstract

The H+-ATPase activity of mitochondria from the rat brain, liver heart and skeletal muscles was studied as affected by 1 at. of oxygen pressure (60 min), 5 at. (10 min) and 5 at. up to the convulsive and terminal states. The effect of 1 at. of oxygen pressure for 60 min and 5 at. for 10 min. causes an increase in the H+-ATPase activity of mitochondria of the investigated tissues. But under convulsive and terminal stages of 5 at. hyperbaric oxygenation the activity of H+-ATPase decreases, and to the greatest extent in the brain mitochondria.

摘要

研究了1个大气压的氧压(60分钟)、5个大气压(10分钟)以及5个大气压直至惊厥和终末期状态对大鼠脑、肝、心脏和骨骼肌线粒体H⁺-ATP酶活性的影响。1个大气压的氧压作用60分钟和5个大气压作用10分钟会使被研究组织线粒体的H⁺-ATP酶活性增加。但在5个大气压高压氧治疗的惊厥和终末期阶段,H⁺-ATP酶活性降低,且在脑线粒体中降低程度最大。

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