Laboratory of Asymmetric Catalysis and Synthesis, EPFL SB ISIC LCSA, BCH 4305, 1015, Lausanne, Switzerland.
Angew Chem Int Ed Engl. 2018 Apr 3;57(15):4039-4042. doi: 10.1002/anie.201801300. Epub 2018 Mar 6.
Secondary 1,3,2-diazaphospholenes have a polarized P-H bond and are emerging as molecular hydrides. Herein, a class of chiral, conformationally restricted methoxy-1,3,2-diazaphospholene catalysts is reported. We demonstrate their catalytic potential in asymmetric 1,4-reductions of α,β-unsaturated carbonyl derivatives, including enones, acyl pyrroles, and amides, which proceeded in enantioselectivities of up to 95.5:4.5 e.r.
二级 1,3,2-二氮杂磷烯具有极化的 P-H 键，正在成为分子氢化物。在此，报告了一类手性、构象受限的甲氧基-1,3,2-二氮杂磷烯催化剂。我们证明了它们在不对称 1,4-还原α,β-不饱和羰基衍生物中的催化潜力，包括烯酮、酰基吡咯和酰胺，其对映选择性高达 95.5:4.5 e.r.
