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[肺动脉瓣狭窄的非手术治疗]

[Non-surgical treatment of pulmonary valve stenosis].

作者信息

Losay J, Petit J, Leriche H, Binet J P

出版信息

Arch Fr Pediatr. 1986 Jun-Jul;43(6):377-81.

PMID:2946272
Abstract

Percutaneous pulmonary valve valvuloplasty was attempted 17 times in 16 infants and children aged 15 days to 18 years. Valvuloplasty was performed during cardiac catheterization without general anesthesia. Balloon catheter was positioned across the pulmonary valve using a guide wire previously introduced in the right or left pulmonary artery. All patients experienced a decrease in the right ventricular peak systolic pressure from 111.5 +/- 35.9 to 69 +/- 28.9 mmHg (p less than 0.001), a decrease in the ratio of right ventricular pressure to systemic systolic pressure from 1.08 +/- 0.34 to 0.65 +/- 0.28 (p less than 0.001) and a decrease in right ventricular to pulmonary artery gradient from 88.52 +/- 37.2 to 54.82 +/- 29.4 mmHg (p less than 0.001). A child with a history of postoperative seizures had convulsions after the procedure and died 72 hours later. Four other patients are considered as a failure of the technique, 4 had clear hemodynamic improvement but right ventricular pressure remained above 50 mmHg, and 8 had satisfactory relief of their stenosis with a right ventricular pressure below or equal to 50 mmHg and a right ventricular to pulmonary artery gradient below 30 mmHg. These good results were confirmed in 2 patients, one year after the dilatation. Percutaneous balloon valvuloplasty is probably now the best treatment for pulmonary valvular stenosis. Short-term and results at distance from the procedure are good, and morbidity and cost are less than those for a surgical cure.

摘要

对16例年龄在15天至18岁的婴幼儿及儿童尝试进行了17次经皮肺动脉瓣成形术。瓣膜成形术在心脏导管插入术期间进行,无需全身麻醉。使用先前插入右或左肺动脉的导丝将球囊导管置于肺动脉瓣上。所有患者的右心室收缩压峰值从111.5±35.9 mmHg降至69±28.9 mmHg(p<0.001),右心室压力与体循环收缩压之比从1.08±0.34降至0.65±0.28(p<0.001),右心室与肺动脉压差从88.52±37.2 mmHg降至54.82±29.4 mmHg(p<0.001)。一名有术后癫痫病史的儿童在术后发生惊厥,72小时后死亡。另外4例患者被认为手术技术失败,4例血流动力学有明显改善但右心室压力仍高于50 mmHg,8例狭窄得到满意缓解,右心室压力低于或等于50 mmHg,右心室与肺动脉压差低于30 mmHg。扩张术后一年,2例患者证实了这些良好结果。经皮球囊瓣膜成形术可能是目前治疗肺动脉瓣狭窄的最佳方法。手术的短期及远期效果良好,发病率和费用低于外科治疗。

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