Morse Anne Marie, Sanjeev Kothare
Division of Child Neurology and Sleep Medicine, Geisinger Medical Center, Danville, PA 17820, USA.
Division of Pediatric Neurology, Pediatric Sleep Program (Neurology), Department of Pediatrics, Cohen Children's Medical Center, Lake Success, NY 11042, USA.
Med Sci (Basel). 2018 Feb 15;6(1):16. doi: 10.3390/medsci6010016.
Narcolepsy and psychiatric disorders have a significant but unrecognized relationship, which is an area of evolving interest, but unfortunately, the association is poorly understood. It is not uncommon for the two to occur co-morbidly. However, narcolepsy is frequently misdiagnosed initially as a psychiatric condition, contributing to the protracted time to accurate diagnosis and treatment. Narcolepsy is a disabling neurodegenerative condition that carries a high risk for development of social and occupational dysfunction. Deterioration in function may lead to the secondary development of psychiatric symptoms. Inversely, the development of psychiatric symptoms can lead to the deterioration in function and quality of life. The overlap in pharmaceutical intervention may further enhance the difficulty to distinguish between diagnoses. Comprehensive care for patients with narcolepsy should include surveillance for psychiatric illness and appropriate treatment when necessary. Further research is necessary to better understand the underlying pathophysiology between psychiatric disease and narcolepsy.
发作性睡病与精神障碍之间存在着显著但尚未被认识到的关系，这是一个日益受到关注的领域，但遗憾的是，人们对这种关联的理解还很有限。两者共病的情况并不少见。然而，发作性睡病最初常常被误诊为精神疾病，这导致准确诊断和治疗的时间延长。发作性睡病是一种致残性神经退行性疾病，会导致社交和职业功能障碍的高风险。功能恶化可能会导致精神症状的继发。反之，精神症状的出现也会导致功能和生活质量的恶化。药物干预的重叠可能会进一步增加诊断区分的难度。对发作性睡病患者的综合护理应包括对精神疾病的监测，并在必要时进行适当治疗。有必要进行进一步的研究，以更好地理解精神疾病与发作性睡病之间潜在的病理生理学机制。
