Tadrous R, O' Rourke D, Murphy N, Quinn G, Slattery L, Broderick J
Discipline of Physiotherapy, School of Medicine, Trinity College, Dublin, Ireland.
Department of Neurology, St. James's Hospital, Dublin, Ireland.
Int J Clin Health Psychol. 2025 Apr-Jun;25(2):100573. doi: 10.1016/j.ijchp.2025.100573. Epub 2025 May 2.
This study aimed to profile and explore the correlation between health-related quality of life (HRQoL), sleepiness severity and physical performance in a sample of people with narcolepsy type 1 (NT1).
This cross-sectional study took place in a dedicated outpatient narcolepsy clinic. The following variables were evaluated: cardiopulmonary fitness, physical activity, muscle strength, muscle endurance, power. HRQoL was assessed using the Short Form-36 (SF-36) and the Functional Outcome of Sleep Questionnaire (FOSQ). Sleepiness Severity was measured by the Epworth Sleepiness Scale (ESS), and symptom severity was assessed using the Narcolepsy Severity Scale (NSS).
A total of 22 participants (31.53 ± 13.17 years, 56.52 % female) completed the test battery. Physical performance was low across all measures. With the exception of accelerometery (54.17 % compliance), there was full compliance (100 %) with the test battery, indicating its feasibility for people with narcolepsy. Results showed that physical performance and HRQoL were markedly reduced compared to normative values in this sample of people with narcolepsy. Self-reported physical activity was associated with higher health-related quality of life (ρ = 0.41; = 0.05), and greater moderate-vigorous physical activity was associated with higher physical wellbeing (ρ = 0.58; = 0.04). Higher BMI was associated with significantly lower predicted VO₂ Max (0.001), and wall sit duration ( = 0.039).
The influence of physical performance on sleepiness severity and quality of life warrants further investigation, including the possible physical rehabilitation strategies to target physical performance deficits.
本研究旨在剖析并探究1型发作性睡病（NT1）患者样本中健康相关生活质量（HRQoL）、嗜睡严重程度与身体机能之间的相关性。
本横断面研究在一家专门的发作性睡病门诊进行。评估了以下变量：心肺适能、身体活动、肌肉力量、肌肉耐力、功率。使用简短健康调查问卷（SF-36）和睡眠功能结局问卷（FOSQ）评估HRQoL。通过爱泼沃斯嗜睡量表（ESS）测量嗜睡严重程度，并使用发作性睡病严重程度量表（NSS）评估症状严重程度。
共有22名参与者（31.53±13.17岁，56.52%为女性）完成了全部测试。所有测量指标的身体机能均较低。除加速度计测量（依从率54.17%）外，全部测试的依从率为100%，表明该测试对发作性睡病患者具有可行性。结果显示，与该发作性睡病患者样本的标准值相比，身体机能和HRQoL显著降低。自我报告的身体活动与更高的健康相关生活质量相关（ρ = 0.41；P = 0.05），更多的中度至剧烈身体活动与更高的身体健康相关（ρ = 0.58；P = 0.04）。更高的体重指数与显著更低的预测VO₂最大值（P = 0.001）和靠墙静蹲持续时间（P = 0.039）相关。
身体机能对嗜睡严重程度和生活质量的影响值得进一步研究，包括针对身体机能缺陷的可能物理康复策略。
